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Histologic analysis of osteonecrosis of the jaw according to the different aspects on quantitative light-induced fluorescence images
DC Field | Value | Language |
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dc.contributor.author | 정회인 | - |
dc.date.accessioned | 2021-09-29T00:37:11Z | - |
dc.date.available | 2021-09-29T00:37:11Z | - |
dc.date.issued | 2021-06 | - |
dc.identifier.issn | 1572-1000 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/183958 | - |
dc.description.abstract | Background: Recurrence of osteonecrosis of the jaw has been reported after surgery. It is therefore necessary to develop a real-time diagnostic method, which can clearly distinguish the surgical margin from unaffected bone. Methods: We analyzed a sequestrum from a patient with medication-related osteonecrosis of the jaw (MRONJ). Quantitative light induced fluorescence (QLF) was applied to the sequestrum. Results: In this study, QLF demonstrated three types of fluorescence phenomena (Non-red-fluorescence, hyper-red-fluorescence, and hypo-red-fluorescence) on the sequestrum. Histology revealed geographical, microbiological, and immunological differences based on the fluorescence types on QLF. Non-red-fluorescence showed sclerotic and lamellar bone tissue, hyper-red-fluorescence showed an infectious state due to bacterial invasion and osteolysis, and hypo-red-fluorescence indicated predominantly granular tissue with inflammation, and the absence of bone matrix and bacterial colonies. Based on histologic analysis, we speculated that QLF may be a useful real-time diagnostic tool during surgery for MRONJ. Conclusions: In conclusion, QLF can be useful in distinguishing between lamellar and infected bone, which are visually similar; QLF-guided ONJ surgery, preserving the Non-red-fluorescent areas and removing the hyper- and hypo-red-fluorescent areas of bone may be useful. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Bisphosphonate-Associated Osteonecrosis of the Jaw* / diagnosis | - |
dc.subject.MESH | Fluorescence | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Photochemotherapy* / methods | - |
dc.subject.MESH | Photosensitizing Agents | - |
dc.subject.MESH | Quantitative Light-Induced Fluorescence* | - |
dc.title | Histologic analysis of osteonecrosis of the jaw according to the different aspects on quantitative light-induced fluorescence images | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Preventive Dentistry and Public Oral Health (예방치과학교실) | - |
dc.contributor.googleauthor | Yesel Kim | - |
dc.contributor.googleauthor | Hoi-In Jung | - |
dc.contributor.googleauthor | Young-Kyun Kim | - |
dc.contributor.googleauthor | Jeong-Kui Ku | - |
dc.identifier.doi | 10.1016/j.pdpdt.2021.102212 | - |
dc.contributor.localId | A03788 | - |
dc.relation.journalcode | J02519 | - |
dc.identifier.eissn | 1873-1597 | - |
dc.identifier.pmid | 33588059 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1572100021000387 | - |
dc.subject.keyword | Biopsy | - |
dc.subject.keyword | Fluorescent light | - |
dc.subject.keyword | Osteomyelitis | - |
dc.subject.keyword | Osteonecrosis of jaw | - |
dc.subject.keyword | Quantitative light-induced fluorescence | - |
dc.contributor.alternativeName | Jung, Hoi In | - |
dc.contributor.affiliatedAuthor | 정회인 | - |
dc.citation.volume | 34 | - |
dc.citation.startPage | 102212 | - |
dc.identifier.bibliographicCitation | PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, Vol.34 : 102212, 2021-06 | - |
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