Cited 0 times in
Hypernatremia at admission predicts poor survival in patients with terminal cancer: a retrospective cohort study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서민석 | - |
dc.contributor.author | 심재용 | - |
dc.date.accessioned | 2021-09-29T00:30:48Z | - |
dc.date.available | 2021-09-29T00:30:48Z | - |
dc.date.issued | 2020-07 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/183883 | - |
dc.description.abstract | Background: Although palliative care providers, patients, and their families rely heavily on accurate prognostication, the prognostic value of electrolyte imbalance has received little attention. Methods: As a retrospective review, we screened inpatients with terminal cancer admitted between January 2017 and May 2019 to a single hospice-palliative care unit. Clinical characteristics and laboratory results were obtained from medical records for multivariable Cox regression analysis of independent prognostic factors. Results: Of the 487 patients who qualified, 15 (3%) were hypernatremic upon admission. The median survival time was 26 days. Parameters associated with shortened survival included male sex, advanced age (> 70 years), lung cancer, poor performance status, elevated inflammatory markers, azotemia, impaired liver function, and hypernatremia. In a multivariable Cox proportional hazards model, male sex (hazard ratio [HR] = 1.53, 95% confidence interval [CI]: 1.15-2.04), poor performance status (HR = 1.45, 95% CI: 1.09-1.94), leukocytosis (HR = 1.98, 95% CI: 1.47-2.66), hypoalbuminemia (HR = 2.06, 95% CI: 1.49-2.73), and hypernatremia (HR = 1.55, 95% CI: 1.18-2.03) emerged as significant predictors of poor prognosis. Conclusion: Hypernatremia may be a useful gauge of prognosis in patients with terminal cancer. Further large-scale prospective studies are needed to corroborate this finding. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | BioMed Central | - |
dc.relation.isPartOf | BMC PALLIATIVE CARE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypernatremia / blood | - |
dc.subject.MESH | Hypernatremia / complications* | - |
dc.subject.MESH | Hypernatremia / mortality | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neoplasms / blood | - |
dc.subject.MESH | Neoplasms / mortality* | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Survival Analysis | - |
dc.subject.MESH | Terminal Care / methods* | - |
dc.title | Hypernatremia at admission predicts poor survival in patients with terminal cancer: a retrospective cohort study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Family Medicine (가정의학교실) | - |
dc.contributor.googleauthor | Min-Seok Seo | - |
dc.contributor.googleauthor | In Cheol Hwang | - |
dc.contributor.googleauthor | Jaehun Jung | - |
dc.contributor.googleauthor | Hwanhee Lee | - |
dc.contributor.googleauthor | Jae Hee Choi | - |
dc.contributor.googleauthor | Jae-Yong Shim | - |
dc.identifier.doi | 10.1186/s12904-020-00607-z | - |
dc.contributor.localId | A01878 | - |
dc.contributor.localId | A02207 | - |
dc.relation.journalcode | J03600 | - |
dc.identifier.eissn | 1472-684X | - |
dc.identifier.pmid | 32611346 | - |
dc.subject.keyword | Electrolyte imbalance | - |
dc.subject.keyword | Hypernatremia | - |
dc.subject.keyword | Prognosis | - |
dc.subject.keyword | Terminal cancer | - |
dc.contributor.alternativeName | Seo, Min Seok | - |
dc.contributor.affiliatedAuthor | 서민석 | - |
dc.contributor.affiliatedAuthor | 심재용 | - |
dc.citation.volume | 19 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 94 | - |
dc.identifier.bibliographicCitation | BMC PALLIATIVE CARE, Vol.19(1) : 94, 2020-07 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.