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HNF-1β as an immunohistochemical marker for distinguishing chromophobe renal cell carcinoma and hybrid oncocytic tumors from renal oncocytoma

 Jiyeon An  ;  Cheol Keun Park  ;  Moonsik Kim  ;  Jin Woo Joo  ;  Nam Hoon Cho 
 VIRCHOWS ARCHIV, Vol.478(3) : 459-470, 2021-03 
Journal Title
Issue Date
Adenoma, Oxyphilic / chemistry* ; Adenoma, Oxyphilic / mortality ; Adenoma, Oxyphilic / pathology ; Adenoma, Oxyphilic / therapy ; Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor / analysis* ; Carcinoma, Renal Cell / chemistry* ; Carcinoma, Renal Cell / mortality ; Carcinoma, Renal Cell / pathology ; Carcinoma, Renal Cell / therapy ; Diagnosis, Differential ; Down-Regulation ; Female ; Hepatocyte Nuclear Factor 1-beta / analysis* ; Humans ; Immunohistochemistry* ; Keratin-7 / analysis ; Kidney Neoplasms / chemistry* ; Kidney Neoplasms / mortality ; Kidney Neoplasms / pathology ; Kidney Neoplasms / therapy ; Male ; Middle Aged ; Predictive Value of Tests ; Prognosis ; Proto-Oncogene Proteins c-kit / analysis
CD10 ; Chromophobe renal cell carcinoma ; HNF-1β ; Immunohistochemistry ; Marker ; Renal oncocytoma
The histologic features of renal oncocytoma (RO) are similar to those for the more aggressive chromophobe renal cell carcinoma (ChRCC). To assess immunohistochemical markers of the two, the sensitivity and specificity of cytokeratin 7 (CK7) and C-kit, as well as hepatocyte nuclear factor-1β (HNF-1β), were analyzed. Typical cases of ChRCC and RO at Severance Hospital between July 2014 and July 2018 were selected retrospectively. Among 44 cases, 17 were unanimously compatible with ChRCC, 16 were RO, and 11 cases were indeterminate. Samples from all selected cases were used for immunostaining with antibodies against CK7, C-kit, HNF-1β, and CD10. Immunostaining demonstrated complete loss of HNF-1β expression in 11 out of 17 (64.7%) ChRCC cases and a partial, but significant loss in > 50% of tumor cells in the remaining 6 cases (35.3%). In contrast, HNF-1β expression was preserved in tumor cells of RO cases. Fourteen of 17 ChRCC cases (82.4%) were diffusely positive for CK7, whereas cases of RO were focal positive or negative. C-kit staining did not show a significant difference between ChRCC and RO. Two of five ChRCC cases showing diffuse immunoreactivity for CD10 had poor prognoses of local invasion, distant metastasis, or death. Loss of HNF-1β expression is a useful marker with which to diagnose ChRCC, especially in cases with confusing histologic findings or equivocal CK7 staining. Additionally, CD10 staining in high-grade ChRCC aids in diagnosis and prediction of the clinical prognosis.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Moonsik(김문식) ORCID logo https://orcid.org/0000-0002-5804-8790
Park, Cheol Keun(박철근) ORCID logo https://orcid.org/0000-0001-7689-0386
Cho, Nam Hoon(조남훈) ORCID logo https://orcid.org/0000-0002-0045-6441
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