산모 적혈구 불규칙 항체의 유병률 및 임상적 의의

Abstract

This study was undertaken to determine both the prevalence of the red cell irregular antibodies and the clinical significance of such antibodies in pregnant women. Among 1.047 patients who received complete prenatal care at the Severance Hospital, Yonsei Medical Center, 22(2.1%) were found to have irregular antibodies. The encountered irregular antibodies in order of frequency were : anti-D(7), anti-Le^a(5), anti-E(2), anti-Le^b(2), anti-E+c(1), anti-Le^a+b(1), anti-Jr^3(1), warm auto(1), cold(1), and unidentified(1). The antecedent maternal risk factors for development of irreaular antibodies such as previous abortion, Cesarean birth, or blood transfusion were observed in 17 patients(77.3%). Seven of the 22(31.8% 0 patients with irregular antibodies delevered infants with hemolytic disease. Only one of these seven required an exchange transfusion. Of the remaining 15 pregnancies with irregular antibodies, they showed normal perinatal outcomes. Our data suggests that irregular antibody screening in all prenatal patients is clinically useful for predicting the likelihood of hemolytic disease of the newborn.