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Clinical Experience with Conservative Surgery for Vaginal Endodermal Sinus Tumor

 Eui Ho Hwang  ;  Seok Joo Han  ;  Myo Kyung Lee  ;  Chuhl-Joo Lyu  ;  Byung Soo Kim 
 JOURNAL OF PEDIATRIC SURGERY, Vol.31(2) : 219-222, 1996-02 
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use ; Chemotherapy, Adjuvant ; Cyclophosphamide / administration & dosage ; Doxorubicin / administration & dosage ; Endodermal Sinus Tumor / diagnosis ; Endodermal Sinus Tumor / drug therapy ; Endodermal Sinus Tumor / surgery* ; Female ; Humans ; Infant ; Neoplasm Recurrence, Local / drug therapy ; Vaginal Neoplasms / diagnosis ; Vaginal Neoplasms / drug therapy ; Vaginal Neoplasms / surgery* ; Vincristine / administration & dosage ; alpha-Fetoproteins / metabolism
Two cases of vaginal endodermal sinus tumor (EST), a rare pediatric malignancy, were managed with conservative surgery followed by adjuvant chemotherapy. The first case involved a 9-month-old girl with EST of the vagina, who was treated with a partial vaginectomy and VAC regimen (vincristine, actinomycin D, cyclophosphamide) during a 2-year period. The serum alpha-fetoprotein (AFP) level returned to normal after excision of the tumor, and it remained normal throughout the treatment period. There was no evidence of disease 30 months after diagnosis. The second case involved an 8-month-old girl with EST of the vagina, who was treated with local excision of the mass through a vaginotomy. The VAC regimen was administered, but the serum AFP level remained elevated. A follow-up abdominopelvic computed tomography scan, taken 4 months after the operation, showed local recurrence of the tumor. The VAC regimen was then changed to a BEP regimen (bleomycin, etoposide, cisplatin). The serum AFP level returned to normal after 2 courses of the new regimen, and no tumor was visible on the follow-up magnetic resonance imaging study. For vaginal EST, primary conservative surgery and adjuvant chemotherapy are attractive measures to preserve both reproductive and sexual function. The extent of conservative surgery requires at least a partial vaginectomy. Simple tumor excision may not be adequate to achieve cure or to prevent local recurrence, even with adjuvant chemotherapy. The serum AFP level is useful for diagnosing and monitoring vaginal EST in the infant.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Lyu, Chuhl Joo(유철주) ORCID logo https://orcid.org/0000-0001-7124-7818
Han, Seok Joo(한석주) ORCID logo https://orcid.org/0000-0001-5224-1437
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