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한약 복용과 관련된 신병증

Other Titles
 Nephropathies Associated with Hrb Medicine Ingestion 
 최규헌  ;  정현주  ;  박종훈  ;  박형천  ;  강신욱  ;  하성규  ;  이호영  ;  한대석  ;  최인준 
 Korean Journal of Nephrology (대한신장학회지), Vol.15(3) : 365-372, 1996-08 
Journal Title
Korean Journal of Nephrology(대한신장학회지)
Issue Date
Herb medicines are largely prescribed in Asian countries, and are possibly responsible for renal in- sufficiency, such as chinese herbs nephropathy. To elucidate the clinical characterization of herb medi- cine-associated nephropathies in Korea, we analyzed the clinical findings of 6 patients showing renal dysfunction with the history of herb medicine inges- tion in Yonsei university Severance Hospital and Yongdong Severance Hospital, since January 1990, and the histologic findings were also evaluated. The results were as follows. 1) The patients were 2 males and 4 females, and their ages ranged from 21 to 66 years. 2) All patients had history of herb medicine ingestion for 3 days to 12 weeks. The purpose of taking medicines was for slimming in 3, better health in 2, and treatment of back pain in one pa- tient, respectively. 3) There was no oliguric patient, with one excep- tion. Serum creatinine concentration ranges from 1.4 to 3.3, except one patient with 13.9mg/dl. The amount of urinary protein excretion ranged from 288 to 1,440mg/day, except one patient with nephrotic syndrome(6.2g/day). 4) One patient showed eosinophilia(14%) on blood cell count, and 2 patients had renal glycosuria, hypophosphatemia, and hypouricemia. The serologic findings, including complement levels were within normal limits. 5) Histologic findings were diverse, acute intersti- tial nephritis in 3(associated with minimal change disease in 1), chronic interstitial nephritis in 2, and regenerating stage of acute tubular necrosis in one. 6) All patients were managed with withdrawal of the suspected drugs. Three patients had supportive treatment, and 2 patients were treated with predni- solone. One patient received dialysis. 7) Renal functions were restored in 3 patients within 3 months after discontinuation, and 2 patients maintained initial renal insufficiency without further exacerbation. One patient with severe uremia did not recover and was maintained on dialysis for 1 month. In conclusion, herb medicine can be the cause of tubulointerstitial disease, and the potential nephro- toxicity should be considered in therapy with herbal preparations. But further studies in greater number of patients and the identification of specific subs- tance causing nephropathies in herbs should be required.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Shin Wook(강신욱) ORCID logo https://orcid.org/0000-0002-5677-4756
Park, Hyeong Cheon(박형천) ORCID logo https://orcid.org/0000-0002-1550-0812
Choi, Kyu Hun(최규헌) ORCID logo https://orcid.org/0000-0003-0095-9011
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