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Role of Nitric Oxide as an Antioxidant in the Defense of Gastric Cells
DC Field | Value | Language |
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dc.contributor.author | 김경환 | - |
dc.date.accessioned | 2021-09-28T08:28:00Z | - |
dc.date.available | 2021-09-28T08:28:00Z | - |
dc.date.issued | 1996-12 | - |
dc.identifier.issn | 0377-9459 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/183659 | - |
dc.description.abstract | Gatric mucosa is exposed to toxic, reactive oxygen species generated within the lumen. Nitric oxide protected acetaminophen-induced hepatotoxicity by maintaining glutathione homeostasis. The present study examined the role of nitric oxide in mediating hydrogen peroxide - induced damage to gastric cells. Hydrogen peroxide was generated by glucose oxidase acting on f-D-glucose. L-arginine, NG-nitro-L-arginine methyl ester, or NG-nitro-L-arginine were treated to the cells with glucose/glucose oxidase. Lipid peroxidation and nitrite release and cellular content of glutathione were determined. As a result, dose - dependent increase in lipid peroxide production as well as dose - dependent decrease in nitrite release and cellular glutathione content were observed in glucose/glucose oxidase - treated cells. Pretreatment of L-arginine, a substrate for nitric oxide synthase, prevented the increase of lipid peroxide production and the reduction of nitrite release as well as glutathione content. Inhibitors of nitric oxide synthase such as NG-nitro-L-arginine methyl ester and NG-nitro-L-arginine did not protect hydrogen peroxide - induced cell damage. In conclusion, nitric oxide protects gastric cells from hydrogen peroxide possibly by inhibiting lipid peroxidation and by preserving cellular glutathione stores. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | 대한약리학회 | - |
dc.relation.isPartOf | Korean Journal of Pharmacology(대한약리학잡지) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Role of Nitric Oxide as an Antioxidant in the Defense of Gastric Cells | - |
dc.title.alternative | 위선세포의 항산화 방어기전으로의 Nitric Oxide의 역할 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학교실) | - |
dc.contributor.googleauthor | Hyeyoung Kim | - |
dc.contributor.googleauthor | Eunjoo Lee | - |
dc.contributor.googleauthor | Kyung Hwan Kim | - |
dc.contributor.localId | A00311 | - |
dc.relation.journalcode | J04046 | - |
dc.subject.keyword | Nitric oxide | - |
dc.subject.keyword | Antioxidant | - |
dc.subject.keyword | Gastric cells | - |
dc.contributor.alternativeName | Kim, Kyung Hwan | - |
dc.contributor.affiliatedAuthor | 김경환 | - |
dc.citation.volume | 32 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 389 | - |
dc.citation.endPage | 397 | - |
dc.identifier.bibliographicCitation | Korean Journal of Pharmacology (대한약리학잡지), Vol.32(3) : 389-397, 1996-12 | - |
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