불소치약 사용후 시간변화에 따른 구강내 타액의 불소농도 변화에 대한 연구

Abstract

The aim of this research was to evaluate the anticaries efficacy of two type, NaF- and SMFP-containing toothpastes which manufactured in Korea. For these, salivary fluoride concentrations after tooth brushing using of two fluoride containing and no-fluoride containing toothpastes were investigated at clinical trial. Thirty-two healthy adults aged 22~25 years were selected as the subjects. All subjects met the screening criteria of having natural dentition, resided in non-fluoridated areas, and with a normal salivary secretion rate, i.e. > 1.0 ml/minute. A double blind case-control study was carried out to compare the salivary fluoride concentrations after tooth brushing with sodium monofluorophosphate (1,000 ppm), sodium fluoride (1,000 ppm), and no fluoride-containing toothpastes. The participants were randomly assigned to three groups as follows: (a) the group used no fluoride-containing toothpaste, (b) used SMFP-containing toothpaste, and (c) used NaF-containing toothpaste. All of the subjects brushed with 1.5 g test dentifrice for 1 minute and immediately rinsed twice with 40 distilled water and then expectorated saliva/water slurry. Non-stimulated whole saliva samples of all the subjects were collected at 0, 15, 30, 60, 90, 120 minutes after tooth brushing. The saliva samples were centrifuged during 15 minutes and collected supernatant. Low-level TISAB (1ml) were added to 1 ml of the samples. Salivary fluoride concentrations were measured by use of fluoride-sensitive electrode (Orion 9609BN, USA). Statistical analysis of the fluoride concentrations was performed by Kruskal-Wallis test and Wilcoxon rank sum test. 1. Salivary fluoride concentrations immediately after toothbrushing were 1.04 p moV 2 using no fluoride-containing toothpaste group, 28.3 p moV Q using NaF-containing toothpaste group, and 12.18 μ moV Q using SMFP-containing toothpaste group. Toothbrushing with NaF- and SMFP-containing toothpaste group gave higher salivary fluoride concentration than no fluoride-containing toothpaste group, and toothbrushing with NaF-containing toothpaste group gave higher salivary fluoride concentration than SMFP-containing toothpaste group ? (p < 0.05). 2. Salivary fluoride concentrations at 0, 15, 30, 60 minutes after toothbrushing with NaF-containing toothpaste group increased than baseline (p < 0.05). Salivary fluoride concentrations at 0, 15 minutes after toothbrushing with SMFP-containing toothpaste group increased than baseline (p < 0.05). 3. The amount of unstimulated saliva was 0.40 mt/min NaF-containing toothpaste group, 0.45 mE/min SMFP-containing toothpaste group, and 0.40 me/min no fluoride-containing toothpaste group. And there was no statistically significant difference among groups.