진행된 골다공증환자에 있어서 골의 조직형태학적 연구

Abstract

In this study we took iliac bone biopsy in 9 patients with established osteoporosis to assess the correlation between the bone densitometry and histomorphometric findings and to evaluate the effect of long-term of estrogen therapy(duration of treatment ranged 1 to 6 years). We examined the structural changes that occur in trabecular bone by measurement of indirect indices of mean trabecular plate thickenss(MTPT; ranged 91 to 181um)(normal range ; 134+-34), Mean trabecular plate separation (MTPS; ranged 690 to 1925um)(normal range ', 785+-181), mean trabecular bone volume(ranged 11.6 to 26.4%)(normal range ; 26.5+-2.4) and mean osteoid seam width(ranged 1.451 8.783um)(normal range ; 7.3+-1.9). Our data showed that there were a significant negative correlation between MTPS, and Zscores of BMD in vertebral bone and femur neck (r2=0.61, p=0.012; r2= 0.45, p=0.04 resctively). There were a also significant correlation between Z score of vertebral bone densities with osteoid seam width(r2=0.45, p=0.04). TBV was positively correlated with vertebral bone diensities but statistically not significant(r2= 0.44, p=0.0504). Mineral appostional rate was decreased despite of relative long-term treatment of estrogen in most of patients treated with estrogen.