전립선암에서 Alpha-1-antichymotrypsin의 의의 : 면역 조직화학적 연구

Abstract

Predominant ktype of serum prostate speciffic antigen (PSA)k is a complexed-form which is bound to alpha-1-antichymotrypsin (ACT). Major fraction of fserum ACT is sderived from the liver and ACT has recently been demonstrted to be produced by PSA-producing prostatic epithelium as well. However,d the feature and significance of prostate-derived ACT remain ill-defined. We herein immunohistolchemically studied profstatic tissues in 40 patientss with prostate cancer and 20 paktients with bengin prostatic hyperplasia (PPH) using antibodey to ACT, kcytokeratin AE3 and chromograin A. IN normal portion of prostate, sejcretory epithelia of central zone and peripheral zone, and basal cells and neuroendocrine cells of peripheral zone showed positive staining for ACT. Bfenign kbhyper5plastic prostatic gland did not stain for ACT. On the study of prostate cancer tissues, relatively increqased staining for ACT were found in solid and infiltrative type of cancer cells and high grade cnacer cells. High intensity staining for ACT were observed in normal prostatic tissues adjacent to invasive cancer cells. In conclusions, basal cells as well as secretory epithelia of the normal prostate gland may be the source of serum ACT. ACT production by prostate cancer may be closely related with its malignant and invasive potential.