호흡기 알레르기 환자의 버섯포자 항원 감작률

Abstract

For evaluation of sensitization of basidiospores in respiratory allergic diseases, we tested skin prick tests of 14 extracts of basidiospores which were made from spore prints of 13 wild mushrooms and one cultivated mushroom, Ganoderma lucidnm. Final concentration of spore extracts for skin test was 1:100 w/v in 0.4% phenolized 50% glycerinized saline so- lution. The following results were obtained: 1) Skin reactivity of study subjects to basidospore extracts ranged 1.5% to 9.5 %, and the basidiospore extracts inducing skin test reactiviy in 2 5% of patients include extracts of spore Collybia confluens(7.5%), Hebeloma sp.(9.0%), Cbu&mansiella gatyphylla(5.% ), Suillns bovinus(9.5% ). Forty subjects(20% ) in 200 patients had positive skin reaction to one or more basidio- spores, snd 11 patients showed positive results to five of more basidiospores. 2) The positive group to basidiospore extracts showed significantly higher reactivity to common inhalant allergens than negatiye group. In subjects reacting to both, there appears to be relationship between skin reactivity scores of basidiospores and 9 common inhalant allergens. 3) Specific IgE of basidiospore extracts was not able be detected on ELISA in the patients sera. According to above results, basidiospores seem to be potentially important aeroallergens in respiratory allergic diseases in Korea. Therefore, we believe that further studies using highly qualified basidiospore extracts shoud be warranted.