CS-3000 Plus 혈액성분채집기 : A-35 Collection Chamber와 PLT-30 Collection Chamber 채료적 백혈구성분채집술의 임상적 유용성

Abstract

Background: recently, it has been established that plateletpheresis needs more efficiency and shorter ocessing time. Fenwall laboratories developed a new collection chamber for CS-3000 Plus, PLT-30TM ollection chamber, which can reduce the processing time with efficient collection, We evaluated the LT-30TM collection chamber by comparing it with A-35 collection chamber that has been used as a andard collection chamber of CS-3000 Plus. Us methods: Thirty platelet collection procedures were performed using the CS 3000 Plus with A-35 ollection chamber and PLT-30TM collection chamber. The changes of the hematologic parameters tween pre-and post-donation in donors and the total platelets yields and the contaminated WBCs in the ateletpheresis products were evaluated. In processing, the yield predictor calibration was adjusted to 90 and 1.13 in A-35 and PLT-30TM respectively. Yield predictors of pheresis were the same as 3.5×10E11 both and end point volumes were calculated from the CS-3000 Plus. Processing volume and ocessing times were compared between A-35 and PLT-30TM groups. Results: With PLT-30TM collection chamber 3.38±0.72×10E11/L platelets were harvested, whereas 3.20±73×10E11/L were collected with A-35 collection chamber. Which was not significantly different. But ocessing time with the PLT-30TM collection chamber was more reduced than that with the A-35 collection amber by about 20 minutes (PLT-30TM: 88.6±8.4 min, A-35: 106.7±11.7min). Collection efficiency of T-30TM chamber was 50.7±12.5% and that of A-35 chamber was 44.4±8.8%. The leukocyte contamination the platelet concentrates were not statistically different (PLT-30TM: 0.0-3.6×10E6, A-35: 0.1-4.1×10E6). Conclusions: PLT-30TM collection chamber has the advantages of shortening the donation time and decreasing the processing volume with better collection efficiency and flexibility of Platelet concentrate volume.