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거세후 재발한 전립선암에서 면역조직화학적 안드로젠수용체의 변화

Other Titles
 Immunohistochemical Androgen Receptor Change of Relapsed Prostate Cancer after Castration 
Authors
 최학룡  ;  한상원  ;  심봉석  ;  박영요  ;  권성원 
Citation
 Korean Journal of Urology (대한비뇨기과학회지), Vol.37(11) : 1239-1246, 1996-11 
Journal Title
KOREAN JOURNAL OF UROLOGY(대한비뇨기과학회지)
ISSN
 0494-4747 
Issue Date
1996-11
Keywords
Immunohistochemistry ; Androgen receptor ; Prostate cancer
Abstract
We tried to find out any differences between initial characteristics of androgen receptors and of relapse after castration in 6 stage D2 prostatic cancer (mean age, 68.7+-4.6) (Gleason score 5, 8, 9 ; 1,3, 2 patients respectively), with immunohistochemical expression using the mouse monoclonal antibody against human androgen receptor. The prostate specimens were obtained by either transrectal needle biopsy or transurethral resection at the time of initial diagnosis and of relapse following castration. The age matched 6 benign prostatic hyperplasia (BPH) specimens were used as control. 200 cancer cells were chosen and staining intensity of each nuclei was graded (O-absent, +1-weak, +2-moderate, +3-strong) from randomly selected and photographed from 10 different fields of each specimen. The means of staining intensity of nuclei from BPH and prostatic cancer before treatment were 1.93+-0.03 and 1.59+-0.03 respectively (p<0.05). At the time of relapse after bilateral orchiectomy (mean, 24.5 +- 5.0 months), the mean staining intensity of nuclei of all cancer patients (1.38 +- 0.03) was significantly different from that of before treatment (p<0.05). But in individual comparison, we could find the decrement in only 2 patients. The intervals of relapse from castration of these two patients (29 and 32 months) were longer than the mean of 6 patients. In conclusion, androgen receptors are still expressed significantly after castration in prostatic cancer. In some patients (2/6), castration down regulates the expression of androgen receptors and the down regulation closely correlated with the relapse time.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Han, Sang Won(한상원) ORCID logo https://orcid.org/0000-0003-0941-1300
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/183313
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