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Evaluation of cardiac sympathetic neuronal integrity in diabetic patients using iodine-123 metaiodobenzylguanidine

Authors
 Sun Jung Kim  ;  Jong Doo Lee  ;  Young Hoon Ryu  ;  Pyoung Jeon  ;  Yong Woon Shim  ;  Hyung Sik Yoo  ;  Chang Yun Park  ;  Seung Gil Lim 
Citation
 EUROPEAN JOURNAL OF NUCLEAR MEDICINE, Vol.23(4) : 401-406, 1996-04 
Journal Title
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
ISSN
 0340-6997 
Issue Date
1996-04
MeSH
3-Iodobenzylguanidine ; Adult ; Aged ; Autonomic Nervous System Diseases / diagnostic imaging* ; Diabetic Neuropathies / diagnostic imaging* ; Epinephrine / urine ; Female ; Heart / diagnostic imaging* ; Humans ; Iodine Radioisotopes* ; Iodobenzenes* ; Male ; Middle Aged ; Norepinephrine / urine ; Sympathetic Nervous System / physiopathology ; Tomography, Emission-Computed, Single-Photon
Abstract
Autonomic dysfunction is associated with increased mortality in diabetic patients. To evaluate the cardiac autonomic dysfunction in these patients, a prospective study was undertaken using iodine-123 metaiodobenzylguanidine (MIBG) single-photon emission tomography (SPET). The study groups consisted of ten diabetic patients with cardiac autonomic neuropathy (group I) and six without autonomic neuropathy (group II). Autonomic nervous function tests, thallium scan, radionuclide ventriculographic data including ejection fraction and wall motion study, and 24-h urine catecholamine levels were evaluated. 123I-MIBG SPET was performed at 30 min and 4h following injection of 3 mCi of 123I-MIBG in groups I and II and in normal subjects (n=4). On planar images, the heart to mediastinum (H/M) ratio was measured. Defect pattern and severity of MIBG uptake were qualitatively analysed on SPET. Compared with control subjects, diabetic patients had a reduced H/M ratio regardless of the presence of clinical autonomic neuropathy. There was no difference in H/M ratio between groups I and II. On SPET images, focal or diffuse defects were demonstrated in all patients in group I, and in five of the six patients in group II. The extent of defects tended to be more pronounced in group I than in group II. In conclusion, 123I-MIBG scan was found to be a more sensitive method than clinical autonomic nervous function tests for the detection of autonomic neuropathy in diabetes.
Full Text
http://link.springer.com/article/10.1007/BF01247368
DOI
10.1007/BF01247368
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
Lee, Jong Doo(이종두)
Lim, Sung Kil(임승길)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/183278
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