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Assembly Specific Binding and Crystallization of a Human TCR αβ with an MHC:TAX Peptide and the Class I MHC Molecule HLA-A2
DC Field | Value | Language |
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dc.contributor.author | 김종선 | - |
dc.date.accessioned | 2021-09-28T07:53:06Z | - |
dc.date.available | 2021-09-28T07:53:06Z | - |
dc.date.issued | 1996-12 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/183251 | - |
dc.description.abstract | T lymphocytes use TCR-alphabeta to bind and to recognize complexes of antigenic peptides bound to MHC proteins located at the surface of APCs. We have assembled and crystallized this intercellular complex of TCR/peptide/MHC from soluble human TCR-alphabeta and soluble peptide/HLA-A2 complexes. The soluble TCR-alphabeta binds specifically to its in vivo ligand, the complex of HLA-A2, and a peptide from the Tax protein of human T lymphotropic virus type 1. The soluble TCR also binds in vitro to an altered peptide ligand, which appears to be a partial agonist in T cell assays as determined by its ability to elicit different cytolytic and lymphokine secretion responses. Heterodimerization and the antigenic specificity of the TCR do not require its interchain disulfide bond, transmembrane segments, or glycosylations. Crystals of the TCR/peptide/HLA-A2 complex diffract x-rays, providing the means to study in atomic detail the mechanism of Ag-specific cell-cell recognition between T cells and target cells. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | American Association of Immunologists | - |
dc.relation.isPartOf | JOURNAL OF IMMUNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Amino Acid Sequence | - |
dc.subject.MESH | Crystallography, X-Ray | - |
dc.subject.MESH | Disulfides / chemistry | - |
dc.subject.MESH | Gene Products, tax / immunology | - |
dc.subject.MESH | Gene Products, tax / ultrastructure* | - |
dc.subject.MESH | HLA-A2 Antigen / ultrastructure* | - |
dc.subject.MESH | HTLV-I Antigens / immunology* | - |
dc.subject.MESH | Human T-lymphotropic virus 1 / immunology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Macromolecular Substances | - |
dc.subject.MESH | Molecular Sequence Data | - |
dc.subject.MESH | Protein Binding | - |
dc.subject.MESH | Protein Conformation | - |
dc.subject.MESH | Protein Folding | - |
dc.subject.MESH | Receptors, Antigen, T-Cell, alpha-beta / metabolism | - |
dc.subject.MESH | Receptors, Antigen, T-Cell, alpha-beta / ultrastructure* | - |
dc.subject.MESH | Structure-Activity Relationship | - |
dc.title | Assembly Specific Binding and Crystallization of a Human TCR αβ with an MHC:TAX Peptide and the Class I MHC Molecule HLA-A2 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.googleauthor | David N. Garboczi | - |
dc.contributor.googleauthor | Ursula Utz | - |
dc.contributor.googleauthor | Partho Chosh | - |
dc.contributor.googleauthor | Alpna Seth | - |
dc.contributor.googleauthor | Jongsun Kim | - |
dc.contributor.googleauthor | Esther A. E. | - |
dc.contributor.googleauthor | VanTienhven | - |
dc.contributor.googleauthor | William E. Biddison | - |
dc.contributor.googleauthor | Don C. Wiley | - |
dc.contributor.localId | A00921 | - |
dc.relation.journalcode | J01450 | - |
dc.identifier.eissn | 1550-6606 | - |
dc.identifier.pmid | 8955188 | - |
dc.identifier.url | https://www.jimmunol.org/content/157/12/5403.long | - |
dc.contributor.alternativeName | Kim, Jong Sun | - |
dc.contributor.affiliatedAuthor | 김종선 | - |
dc.citation.volume | 157 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 5403 | - |
dc.citation.endPage | 5410 | - |
dc.identifier.bibliographicCitation | JOURNAL OF IMMUNOLOGY, Vol.157(12) : 5403-5410, 1996-12 | - |
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