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Gamma/delta T lymphocytes in the BCG granulomatous lesions

Authors
 Dong Soo Kim  ;  Ki Young Lee  ;  Woo Ick Yang  ;  Seok Joo Han  ;  Eui Ho Hwang 
Citation
 YONSEI MEDICAL JOURNAL, Vol.37(5) : 319-324, 1996-10 
Journal Title
YONSEI MEDICAL JOURNAL
ISSN
 0513-5796 
Issue Date
1996-10
MeSH
Female ; Granuloma / immunology ; Granuloma / pathology* ; Humans ; Infant ; Lymph Nodes / pathology ; Male ; Mycobacterium bovis* ; Receptors, Antigen, T-Cell, gamma-delta / analysis* ; T-Lymphocytes / immunology* ; Tuberculosis / immunology ; Tuberculosis / pathology*
Abstract
Recent studies in man and animal models have demonstrated that TCR-γδ-bearing T cells (γδ T cells) are activated by mycobacteria and accumulate in the sites of mycobacterial infection. Although the function of γδ T cells remains unclear, some data suggest a potential role for these cells in the granulomatous immune response. To address the presence of γδ T cells within the BCG granulomas, we have characterized the TCR phenotype of T-lymphocytes present in the BCG granulomatous lesion immunohistochemically using a monoclonal antibody to TCR δ1 and others. Fairly large numbers of γδ T cells were located at the periphery of the BCG granulomas without necrosis and most of them also expressed CD8. However, γδ T cells were rarely present in the granulomas with central caseous necrosis, calcification and fibrotic changes. With these results, it might be speculated that the CD8+ γδ T lymphocytes participate in the BCG granuloma formation mainly in the early stage.
Files in This Item:
T199601031.pdf Download
DOI
10.3349/ymj.1996.37.5.319
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Soo(김동수)
Han, Seok Joo(한석주) ORCID logo https://orcid.org/0000-0001-5224-1437
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/183211
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