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Candida albicans의 표면 iC3b 수용체 발현 및 혈관 내피세포에 대한 유착

Other Titles
 Expression of iC3b Receptor on Candida albicans and Its Role on Adhesion of the Yeast to Human Dermal Microvascular Endothelium 
 이광훈  ;  윤문수  ;  윤경한  ;  최현주 
 Korean Journal of Medical Mycology (대한의진균학회지), Vol.1(1) : 35-45, 1996-03 
Journal Title
Korean Journal of Medical Mycology(대한의진균학회지)
Issue Date
Background: The adherence of microorganisms to host tissue is an important process in the pathogenesis of fungal infection. A protein that shares antigenic and structural homology with the α-subunit of leukocyte adhesion glycoprotein CD11b/CD18, also known as iC3b receptor, Mo-1 or Mac-1, has been isolated from the surface of C. albicans.
Objective: This study was done to observe the changes in the expression of iC3b receptor on C. albicans by glucose or immunosuppressive agents and to elucidate the effect of glucose and anti-iC3b receptor antibodies on adhesion between human dermal microvascular endothelial cells(HDMEC) and C. albicans.
Methods: We utilized immunofluorescence study and immunofluorescent flow cytometry and the binding assay of C. albicans to cultured HDMEC in vitro and blocking assay using monoclonal antibody were performed.
Results: Immunofluorescence study and immunofluorescent flow cytometric analysis demonstrated surface expression of iC3b receptor on C. albicans. The expression of surface iC3b receptor on C. albicans in creased in a dose dependent manner with increasing concentrations of glucose, cyclophosphamide and prednisolone. The adherence of C. albicans to HDMEC correlated positively with glucose levels. The adherence of C. albicans to HDMEC decreased significantly by the treatment with anti-iC3b receptor antibodies.
Conclusion: The results suggest that iC3b receptors should be involved in the adherence of C. albicans to vascular endothelial cells and may be involved in the
pathogenesis of hematogenous candidiasis.
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1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Kwang Hoon(이광훈)
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