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항암화학요법제 투여중인 암환자의 빈혈에 대한 Recombinant Human Erythropoietin (Eprex®)의 임상 효과

Other Titles
 Clinical Effects of Recombinant Human Erythropoietin(Eprex^(®)) in Anemic Patients with Cancer Receiving Chemotherapy 
 홍대식  ;  강윤구  ;  권기영  ;  김병국  ;  김선영  ;  감주항  ;  김준석 
 Korean Journal of Biological Response Modifiers (한국 BRM학회지), Vol.6(1) : 111-122, 1996-01 
Journal Title
Korean Journal of Biological Response Modifiers(한국 BRM학회지)
Issue Date
Background : Patients with advanced cancer frequently experience clinically significant anemia, which is often exacerbated by myelosuppressive chemotherapy. Myelosuppressive chemotherapy impairs erythropoiesis which may not fully recover between treatment cycles.
Method: In an effort to evaluate a possible role for recombinant human erythropoietin (rHuEPO)in anemic patients with cancer receiving chemotherapy, we studied 106 anemic cancer patients receiving cyclic combination chemotherapy in a prospective multicenter, randomized, open labeled, phase III study. Eligibility was restricted to patients with lung cancer, stomach cancer and colon cancer. The patients were randomized to receive conventional support alone(control patients) or rHuEPO(150 u/kg) subcutaneously 3 times a week for 12 weeks.
Result : In the 90 patients analyzed to date, response to rHuEPO therapy was assessed by measuring changes in hematocrit level, and transfusion requirements.
The increase in hematocrit in the rHuEPO treated group compared with control group was statistically significant(P=.0001) as measured by percentage point of change. Patients with lung cancer or gastrointestinal cancer responded equally well to rHuEPO treatment. There was a trend toward the reduction in mean units of blood transfused per patient during week 4 and 8 therapy in rHuEPO-treated patients compared with control patients (0.11±0.07 u versus 0.58 ±0.20 u pConclusion: We conclude that rHuEPO is safe and effective for reversing anemia related to chemotherapy for cancer.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Joo Hang(김주항)
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