만성 비세균성 전립선염 환자의정자운동성에 대한 연구-항정자항체와 정장액 cytokine 및 정장액성분과의 상관관계

Abstract

Seminal inflammatory white blood cells in patients with chronic nonbacterial prostatitis may be related to the decrease of semen quality affecting fertility. So we evaluated the change of sperm motility, the levels of antisperm antibodies, the seminal levels of various cytokines and the change of seminal biochemical compositions that may affect sperm motility in the control group. We also examined chronic nonbacterial prostatitis with pyospermia to establish the role of seminal inflammatory white blood cells on alteration of sperm motility. The relation between various affecting factors and sperm motility were also evaluated. Titers of antisperm antibodies were low in patients with chronic nonbacterial prostatitis. Interleukin-1a and interleukin-8 of seminal inflammatory cytokines were present in increased quantities in patients with chronic nonbacterial prostatitis and interleukin-8 of these increases were correlated to sperm motility. Among the seminal composition, the level of zinc was decreased significantly which was not correlated to sperm motility. In conclusion, sperm motility was decreased and alterations in interleukin-8 of seminal cytokines were correlated with sperm motility in chronic nonbacterial prostatitis.