건강인에서 연령,성별 및 ABO 혈액형에 따른 혈장 von Willebrand Factor 항원 농도의 차이

Abstract

Background: The diagnosis of von Willebrand disease(vWD) is based on the demonstration of decreased plasma von Willebrand factor antigen(vWF:Ag) levels. However, plasma vWF:Ag levels have been shown to be substantially lower in persons of blood type 0 in the Caucasian population. But it is unclear how variable these ranges are in different racial and ethnic groups, and a specific normal ranges should be established by each laboratory. Methods: Plasma concentrations of vWF:Ag were determined by enzyme linked immunosorbent assay in 322 healthy individuals with different ABO blood groups(A=126, B=66, AB=38, 0=92). We investigated ABO, age and sex related difference in plasma von Willebrand antigen levels by using one way analysis of variance and t-test. Results: Plasma vWF:Ag concentration was affected by the ABO blood group, showing significantly low values in group 0 individuals(median[Interquantile range] :O; 77.1[41.1113.1]%, p<0.001). There was no significant difference in the levels among the other blood groups(A:94.3 [53.4134.7]%, B:94.7[53.1-136.7]%, AB:102.4[54.6-150.2]%, respectively). vWF:Ag level was also affected by age, showing significantly higher values in group of age 48.57 compared to other younger age groups. But sex didn´t significantly influence the levels of plasma vWF:Ag. Conclusion: Plasma vWF:Ag levels in healthy Korean population were substantially lower in persons of blood group 0. Therefore ABO blood group adjusted normal ranges should be considered in diagnosing vWD. Furthermore, patients with low value should have their ABO blood type determined so that they can be evaluated against the proper control population.