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만성 신부전 환자에서 혈액투석 전후의 혈장 von Willebrand factor 항원 변화

Other Titles
 Plasma Levels of von Willebrand Factor antigen before and after Hemodialysis in Patients with Chronic Renal Failure 
 이경아  ;  이안나  ;  송경순 
 Korean Journal of Hematosis and Thrombosis (한국지혈혈전학회지), Vol.3(2) : 99-103, 1996-12 
Journal Title
Korean Journal of Hematosis and Thrombosis(한국지혈혈전학회지)
Issue Date
Background: Since von Willebrand factor(vWF) has been first implicated in the pathogenesis of uremic bleeding by Kazatchkine et al.(1976), several subsequent studies have demonstrated the presence of increased levels of plasma vWF in renal failure. After initiation of hemodialysis, the mortality from the uremic bleeding diasthesis improved significantly. However, there are numerous reports of life-threatening bleeding in patients undergoing chronic hemodialysis. Therefore, we evaluated the change of plasma vWF:Ag levels before and after hemodialysis.
Methods: vWF:Ag concentrations were determined by enzyme linked immunoassay in pre-and posthemodialysis plasma of 20 uremic patients and 20 healthy controls. T-test was used to compare vWF:Ag concentrations of pre-vs posthemodialysis and controls vs prehemodialysis.
Results: Plasma concentrations of vWF:Ag in predialysis was elevated by 114.3±24.6% compared to healthy controls(92.4 ± 17.2 %)(p=0.002). No significant difference was found between the pre-and posthemodialysis(114.3±24.6%, 118.0±19.0, respectively, p=0.4).
Conclusions: Plasma concentrations of vWF:Ag in uremic patients were higher than in healthy controls. The change of plasma vWF:Ag after hemodialysis was not observed.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Song, Kyung Soon(송경순)
Lee, Kyung A(이경아) ORCID logo https://orcid.org/0000-0001-5320-6705
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