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p53 protein expression in extrahepatic bile duct cancer

Authors
 Yong Chan Lee  ;  Si Young Song  ;  Jae Bock Chung  ;  Jin Kyung Kang  ;  In Suh Park 
Citation
 YONSEI MEDICAL JOURNAL, Vol.37(2) : 112-117, 1996-04 
Journal Title
YONSEI MEDICAL JOURNAL
ISSN
 0513-5796 
Issue Date
1996-04
MeSH
Adult ; Aged ; Bile Duct Neoplasms / chemistry* ; Bile Duct Neoplasms / mortality ; Bile Ducts, Extrahepatic* ; Female ; Humans ; Immunohistochemistry ; Male ; Middle Aged ; Survival Rate ; Tumor Suppressor Protein p53 / analysis* ; Tumor Suppressor Protein p53 / immunology
Abstract
p53 mutations, a tumor suppressor gene located on chromosome 17p, are the most common genetic alterations found in human cancers. Although the p53 expression or mutation has been investigated in a variety of cancers there have been very few studies in extrahepatic bile duct cancers. In this study, we investigated the immunohistochemical expression of p53 in formalin fixed paraffin embedded archival specimens of 36 extrahepatic bile duct cancers in which p53 expression was found in eighteen (50%) cases. There was no significant difference in age, gender, size of tumor, histologic grade, extent of tumor involvement, lymph node metastasis and tumor resectability according to p53 immunoreactivity. Comparison of survival duration according to p53 expression showed no significant difference. In conclusion, we reported 50 percent of p53 expression in extrahepatic bile duct cancers by immunohistochemical staining and we found no prognostic significance of p53 expression in dinicopathologic parameters.
Files in This Item:
T199600282.pdf Download
DOI
10.3349/ymj.1996.37.2.112
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Song, Si Young(송시영) ORCID logo https://orcid.org/0000-0002-1417-4314
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/183096
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