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Impact of age on coronary artery plaque progression and clinical outcome: A PARADIGM substudy

DC FieldValueLanguage
dc.contributor.author김민관-
dc.contributor.author이병권-
dc.contributor.author장혁재-
dc.date.accessioned2021-07-22T08:36:53Z-
dc.date.available2021-07-22T08:36:53Z-
dc.date.issued2021-05-
dc.identifier.issn1934-5925-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/183023-
dc.description.abstractBackground: The association of age with coronary plaque dynamics is not well characterized by coronary computed tomography angiography (CCTA). Methods: From a multinational registry of patients who underwent serial CCTA, 1153 subjects (61 ± 5 years old, 61.1% male) were analyzed. Annualized volume changes of total, fibrous, fibrofatty, necrotic core, and dense calcification plaque components of the whole heart were compared by age quartile groups. Clinical events, a composite of all-cause death, acute coronary syndrome, and any revascularization after 30 days of the initial CCTA, were also analyzed. Random forest analysis was used to define the relative importance of age on plaque progression. Results: With a 3.3-years' median interval between the two CCTA, the median annual volume changes of total plaque in each age quartile group was 7.8, 10.5, 10.8, and 12.1 mm3/year and for dense calcification, 2.5, 4.6, 5.4, and 7.1 mm3/year, both of which demonstrated a tendency to increase by age (p-for-trend = 0.001 and < 0.001, respectively). However, this tendency was not observed in any other plaque components. The annual volume changes of total plaque and dense calcification were also significantly different in the propensity score-matched lowest age quartile group versus the other age groups as was the composite clinical event (log-rank p = 0.003). In random forest analysis, age had comparable importance in the total plaque volume progression as other traditional factors. Conclusions: The rate of whole-heart plaque progression and dense calcification increases depending on age. Age is a significant factor in plaque growth, the importance of which is comparable to other traditional risk factors. Clinical trial registration: URL: http://www.clinicaltrials.gov. Unique identifiers: NCT02803411.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfJOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAdult-
dc.subject.MESHAge Factors-
dc.subject.MESHAged-
dc.subject.MESHComputed Tomography Angiography*-
dc.subject.MESHCoronary Artery Disease / diagnostic imaging*-
dc.subject.MESHDisease Progression-
dc.subject.MESHFemale-
dc.subject.MESHHeart Disease Risk Factors-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPlaque, Atherosclerotic*-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHPrognosis-
dc.subject.MESHProspective Studies-
dc.subject.MESHRegistries-
dc.subject.MESHRisk Assessment-
dc.subject.MESHVascular Calcification / diagnostic imaging*-
dc.titleImpact of age on coronary artery plaque progression and clinical outcome: A PARADIGM substudy-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학교실)-
dc.contributor.googleauthorMinkwan Kim-
dc.contributor.googleauthorSeung-Pyo Lee-
dc.contributor.googleauthorSoongu Kwak-
dc.contributor.googleauthorSeokhun Yang-
dc.contributor.googleauthorYong-Jin Kim-
dc.contributor.googleauthorDaniele Andreini-
dc.contributor.googleauthorMouaz H Al-Mallah-
dc.contributor.googleauthorMatthew J Budoff-
dc.contributor.googleauthorFilippo Cademartiri-
dc.contributor.googleauthorKavitha Chinnaiyan-
dc.contributor.googleauthorJung Hyun Choi-
dc.contributor.googleauthorEdoardo Conte-
dc.contributor.googleauthorHugo Marques-
dc.contributor.googleauthorPedro de Araújo Gonçalves-
dc.contributor.googleauthorIlan Gottlieb-
dc.contributor.googleauthorMartin Hadamitzky-
dc.contributor.googleauthorJonathon A Leipsic-
dc.contributor.googleauthorErica Maffei-
dc.contributor.googleauthorGianluca Pontone-
dc.contributor.googleauthorGilbert L Raff-
dc.contributor.googleauthorSanghoon Shin-
dc.contributor.googleauthorByoung Kwon Lee-
dc.contributor.googleauthorEun Ju Chun-
dc.contributor.googleauthorJi Min Sung-
dc.contributor.googleauthorSang-Eun Lee-
dc.contributor.googleauthorDaniel S Berman-
dc.contributor.googleauthorFay Y Lin-
dc.contributor.googleauthorRenu Virmani-
dc.contributor.googleauthorHabib Samady-
dc.contributor.googleauthorPeter H Stone-
dc.contributor.googleauthorJagat Narula-
dc.contributor.googleauthorJeroen J Bax-
dc.contributor.googleauthorLeslee J Shaw-
dc.contributor.googleauthorJames K Min-
dc.contributor.googleauthorHyuk-Jae Chang-
dc.identifier.doi10.1016/j.jcct.2020.09.009-
dc.contributor.localIdA05957-
dc.contributor.localIdA02793-
dc.contributor.localIdA03490-
dc.relation.journalcodeJ01291-
dc.identifier.eissn1876-861X-
dc.identifier.pmid33032975-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S1934592520304482-
dc.subject.keywordAging-
dc.subject.keywordComputed tomography-
dc.subject.keywordCoronary artery disease-
dc.subject.keywordDisease progression-
dc.subject.keywordatherosclerotic plaque-
dc.contributor.alternativeNameKim, Minkwan-
dc.contributor.affiliatedAuthor김민관-
dc.contributor.affiliatedAuthor이병권-
dc.contributor.affiliatedAuthor장혁재-
dc.citation.volume15-
dc.citation.number3-
dc.citation.startPage232-
dc.citation.endPage239-
dc.identifier.bibliographicCitationJOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY, Vol.15(3) : 232-239, 2021-05-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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