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Transient Global Ischemia-Induced Brain Inflammatory Cascades Attenuated by Targeted Temperature Management

DC FieldValueLanguage
dc.contributor.author박유석-
dc.contributor.author범진호-
dc.contributor.author유제성-
dc.contributor.author정성필-
dc.date.accessioned2021-05-26T17:05:20Z-
dc.date.available2021-05-26T17:05:20Z-
dc.date.issued2021-05-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/182984-
dc.description.abstractSudden cardiac arrest leads to a significantly increased risk of severe neurological impairment and higher mortality rates in survivors due to global brain tissue injury caused by prolonged whole-body ischemia and reperfusion. The brain undergoes various deleterious cascading events. Among these damaging mechanisms, neuroinflammation plays an especially crucial role in the exacerbation of brain damage. Clinical guidelines indicate that 33 °C and 36 °C are both beneficial for targeted temperature management (TTM) after cardiac arrest. To clarify the mechanistic relationship between TTM and inflammation in transient global ischemia (TGI) and determine whether 36 °C produces a neuroprotective effect comparable to 33 °C, we performed an experiment using a rat model. We found that TTM at 36 °C and at 33 °C attenuated neuronal cell death and apoptosis, with significant improvements in behavioral function that lasted for up to 72 h. TTM at 33 °C and 36 °C suppressed the propagation of inflammation including the release of high mobility group box 1 from damaged cells, the activation and polarization of the microglia, and the excessive release of activated microglia-induced inflammatory cytokines. There were equal neuroprotective effects for TTM at 36 °C and 33 °C. In addition, hypothermic complications and should be considered safe and effective after cardiac arrest.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherMDPI-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleTransient Global Ischemia-Induced Brain Inflammatory Cascades Attenuated by Targeted Temperature Management-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Emergency Medicine (응급의학교실)-
dc.contributor.googleauthorDae Ki Hong-
dc.contributor.googleauthorYoo Seok Park-
dc.contributor.googleauthorJi Sun Woo-
dc.contributor.googleauthorJu Hee Kim-
dc.contributor.googleauthorJin Ho Beom-
dc.contributor.googleauthorSung Phil Chung-
dc.contributor.googleauthorJe Sung You-
dc.contributor.googleauthorSang Won Suh-
dc.identifier.doi10.3390/ijms22105114-
dc.contributor.localIdA01592-
dc.contributor.localIdA05135-
dc.contributor.localIdA02507-
dc.contributor.localIdA03625-
dc.relation.journalcodeJ01133-
dc.identifier.eissn1422-0067-
dc.subject.keywordpost cardiac arrest care-
dc.subject.keywordtargeted temperature management-
dc.subject.keywordhigh mobility box protein 1-
dc.subject.keywordapoptosis-
dc.subject.keywordinflammation-
dc.subject.keywordmicroglia-
dc.contributor.alternativeNamePark, Yoo Seok-
dc.contributor.affiliatedAuthor박유석-
dc.contributor.affiliatedAuthor범진호-
dc.contributor.affiliatedAuthor유제성-
dc.contributor.affiliatedAuthor정성필-
dc.citation.volume22-
dc.citation.number10-
dc.citation.startPage5114-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.22(10) : 5114, 2021-05-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학교실) > 1. Journal Papers

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