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Impact of 1-Hour Bundle Achievement in Septic Shock

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dc.contributor.author박유석-
dc.contributor.author정성필-
dc.date.accessioned2021-05-26T17:02:07Z-
dc.date.available2021-05-26T17:02:07Z-
dc.date.issued2021-02-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/182959-
dc.description.abstractThis study aimed to address the impact of 1-hr bundle achievement on outcomes in septic shock patients. Secondary analysis of multicenter prospectively collected data on septic shock patients who had undergone protocolized resuscitation bundle therapy at emergency departments was conducted. In-hospital mortality according to 1-h bundle achievement was compared using multivariable logistic regression analysis. Patients were also divided into 3 groups according to the time of bundle achievement and outcomes were compared to examine the difference in outcome for each group over time: group 1 (≤1 h reference), group 2 (1-3 h) and group 3 (3-6 h). In total, 1612 patients with septic shock were included. The 1-h bundle was achieved in 461 (28.6%) patients. The group that achieved the 1-h bundle did not show a significant difference in in-hospital mortality compared to the group that did not achieve the 1-h bundle on multivariable logistic regression analysis (<1 vs. >1 h) (odds ratio = 0.74, p = 0.091). However, 3- and 6- h bundle achievements showed significantly lower odds ratios of in-hospital mortality compared to the group that did not achieve the bundle (<3 vs. >3 h, <6 vs. >6 h, odds ratio = 0.604 and 0.458, respectively). There was no significant difference in in-hospital mortality over time for group 2 and 3 compared to that of group 1. One-hour bundle achievement was not associated with improved outcomes in septic shock patients. These data suggest that further investigation into the clinical implications of 1-h bundle achievement in patients with septic shock is warranted.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherMDPI AG-
dc.relation.isPartOfJOURNAL OF CLINICAL MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleImpact of 1-Hour Bundle Achievement in Septic Shock-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Emergency Medicine (응급의학교실)-
dc.contributor.googleauthorByuk Sung Ko-
dc.contributor.googleauthorSung-Hyuk Choi-
dc.contributor.googleauthorTae Gun Shin-
dc.contributor.googleauthorKyuseok Kim-
dc.contributor.googleauthorYou Hwan Jo-
dc.contributor.googleauthorSeung Mok Ryoo-
dc.contributor.googleauthorYoo Seok Park-
dc.contributor.googleauthorWoon Yong Kwon-
dc.contributor.googleauthorHan Sung Choi-
dc.contributor.googleauthorSung Phil Chung-
dc.contributor.googleauthorGil Joon Suh-
dc.contributor.googleauthorHyunggoo Kang-
dc.contributor.googleauthorTae Ho Lim-
dc.contributor.googleauthorDonghee Son-
dc.contributor.googleauthorWon Young Kim-
dc.identifier.doi10.3390/jcm10030527-
dc.contributor.localIdA01592-
dc.contributor.localIdA03625-
dc.relation.journalcodeJ03556-
dc.identifier.eissn2077-0383-
dc.identifier.pmid33540513-
dc.subject.keyword1-h bundle-
dc.subject.keywordemergency department-
dc.subject.keywordmortality-
dc.subject.keywordoutcome-
dc.subject.keywordsepsis-
dc.subject.keywordseptic shock-
dc.contributor.alternativeNamePark, Yoo Seok-
dc.contributor.affiliatedAuthor박유석-
dc.contributor.affiliatedAuthor정성필-
dc.citation.volume10-
dc.citation.number3-
dc.citation.startPage527-
dc.identifier.bibliographicCitationJOURNAL OF CLINICAL MEDICINE, Vol.10(3) : 527, 2021-02-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학교실) > 1. Journal Papers

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