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Translational cognitive neuroscience of dementia with touchscreen operant chambers

Authors
 Ji Han Lee  ;  So Yeon Cho  ;  Eosu Kim 
Citation
 GENES BRAIN AND BEHAVIOR, Vol.20(1) : e12664, 2021-01 
Journal Title
 GENES BRAIN AND BEHAVIOR 
ISSN
 1601-1848 
Issue Date
2021-01
Keywords
behavior ; dementia ; operant chambers ; touchscreen ; translational research
Abstract
Translational cognitive neuroscience of dementia involves mainly two areas: the validation of newly developed dementia animal models and the preclinical assessment of novel drug candidates in such model animals. To validate new animal models, a multidomain panel (battery) approach is essential in that dementia is, by definition, not merely a memory disorder but rather a multidomain cognitive/behavior disorder: animal modeling with a certain type of dementia would develop cognitive impairments in multiple (two at minimum) domains in a specific order according to unique spreading patterns of its neuropathology. In new drug development, the availability of highly sensitive tools assessing animal cognition is crucial to the detection of cognitive decline at the earliest stage of the disease, which may be an optimal time point to test a drug candidate. Using interspecies translatable (analogous) cognitive tasks would also be necessary to successfully predict the efficacy of drug candidates in subsequent clinical trials. Currently, this translational prediction is seriously limited given discrepancies in behavioral assessment methods between animals and humans in the preclinical and clinical trials, respectively. Since neurodegenerative diseases are often accompanied by not only cognitive but also affective and movement disorders, simultaneous assessment of task-relevant locomotor behavior and motivation is also important to rule out the effects of potential confounders. The touchscreen operant platform may satisfy these needs by offering several advantages over conventional methodology. In this review, we discuss the touchscreen operant chamber system and highlight some of its qualities as a promising and desirable tool for translational research of dementia.
Full Text
https://onlinelibrary.wiley.com/doi/10.1111/gbb.12664
DOI
10.1111/gbb.12664
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Eosu(김어수) ORCID logo https://orcid.org/0000-0001-9472-9465
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182918
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