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Safety and effectiveness of linagliptin in Korean patients with type 2 diabetes: A postmarketing surveillance study

Authors
 Jaehyun Bae  ;  Kee-Ho Song  ;  Jong Suk Park  ;  Jae Hyuk Lee  ;  In-Kyung Jeong  ;  Hyun Jin Kim  ;  Young-Hyo Lim  ;  Jae-Hyoung Cho  ;  Sung Hee Choi  ;  Yoon-Sok Chung  ;  Eun Seok Kang 
Citation
 DIABETES OBESITY & METABOLISM, Vol.23(5) : 1208-1212, 2021-05 
Journal Title
 DIABETES OBESITY & METABOLISM 
ISSN
 1462-8902 
Issue Date
2021-05
Keywords
antidiabetic drug ; linagliptin
Abstract
We designed a postmarketing surveillance study of linagliptin for patients with type 2 diabetes (T2D) in Korea. This prospective, observational, multicentre study investigated the safety and glycaemic effectiveness of linagliptin as monotherapy or combination therapy with other antidiabetic drugs in routine clinical practice. Endpoints were the incidence of adverse drug reactions (ADRs) and the change in HbA1c. Overall, 3119 and 2171 patients were included in the safety and effectiveness analysis sets, respectively. A total of 56 patients (1.8%) experienced ADRs. The most common ADR was gastrointestinal disorders (0.7%), followed by metabolism and nutrition disorders (0.5%). ADRs of special interest, including pancreatic diseases, cardiac diseases and hypoglycaemia, occurred in 12 patients, 11 of whom had hypoglycaemia, while one had a skin lesion. Mean HbA1c change during the study period was -0.8%. Lower body mass index, shorter diabetes duration and higher baseline HbA1c were independently associated with a better effectiveness, while the presence of diabetic complications, dyslipidaemia and the use of sulphonylureas were associated with a poor response. In conclusion, linagliptin showed an excellent safety profile and glycaemic effectiveness in Korean patients with T2D.
Full Text
https://dom-pubs.onlinelibrary.wiley.com/doi/10.1111/dom.14317
DOI
10.1111/dom.14317
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182855
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