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Prognostic Implications of Epilepsy Onset Age According to Relapse Pattern in Patients with Four-Year Remission

Authors
 Soochul Park  ;  Myeongjee Lee 
Citation
 DIAGNOSTICS, Vol.10(12) : 1089, 2020-12 
Journal Title
 DIAGNOSTICS 
Issue Date
2020-12
Keywords
age at onset of epilepsy ; epilepsy ; prognostic factor ; relapse pattern ; remission within 1 year
Abstract
A total of 472 epilepsy patients with a 4-year remission period were divided into 10-year age groups according to age of onset. The relapse patterns during at least 3 years of follow-up were classified as early relapse (ER), late relapse (LR), and seizure-free (SF). The remission probability and multiplicity of prognostic factors were evaluated using univariate and multivariate multinomial logistic analyses. The weighted risk score based on odd ratios (ORs) was used for comparisons of the relative risk of relapse between groups. The group with onset in their 20s had the lowest remission probability among the groups. The risks of relapse in the LR patients and the relative weighted risk score of ER patients in the group with onset in their 20s were 3.11 and 19.44, respectively, which was the highest risk among the age groups. Patients without remission within 1 year had the highest relapse risk, with an OR of 7.18 in ER patients. The OR of relapse in patients with >10 generalized tonic-clonic (GTC) seizures was the second most important prognostic factor in LR patients. The distinct risk and corresponding prognostic factors in LR and ER patients reflected inherent differences between these relapse patterns.
Files in This Item:
T202006949.pdf Download
DOI
10.3390/diagnostics10121089
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Biomedical Systems Informatics (의생명시스템정보학교실) > 1. Journal Papers
Yonsei Authors
Park, Soo Chul(박수철)
Lee, Myeongjee(이명지)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182813
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