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Developmental Roles of FUSE Binding Protein 1 ( Fubp1) in Tooth Morphogenesis

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dc.contributor.author조성원-
dc.date.accessioned2021-05-26T16:41:37Z-
dc.date.available2021-05-26T16:41:37Z-
dc.date.issued2020-10-
dc.identifier.issn1661-6596-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/182804-
dc.description.abstractFUSE binding protein 1 (Fubp1), a regulator of the c-Myc transcription factor and a DNA/RNA-binding protein, plays important roles in the regulation of gene transcription and cellular physiology. In this study, to reveal the precise developmental function of Fubp1, we examined the detailed expression pattern and developmental function of Fubp1 during tooth morphogenesis by RT-qPCR, in situ hybridization, and knock-down study using in vitro organ cultivation methods. In embryogenesis, Fubp1 is obviously expressed in the enamel organ and condensed mesenchyme, known to be important for proper tooth formation. Knocking down Fubp1 at E14 for two days, showed the altered expression patterns of tooth development related signalling molecules, including Bmps and Fgf4. In addition, transient knock-down of Fubp1 at E14 revealed changes in the localization patterns of c-Myc and cell proliferation in epithelium and mesenchyme, related with altered tooth morphogenesis. These results also showed the decreased amelogenin and dentin sialophosphoprotein expressions and disrupted enamel rod and interrod formation in one- and three-week renal transplanted teeth respectively. Thus, our results suggested that Fubp1 plays a modulating role during dentinogenesis and amelogenesis by regulating the expression pattern of signalling molecules to achieve the proper structural formation of hard tissue matrices and crown morphogenesis in mice molar development.-
dc.description.statementOfResponsibilityopen-
dc.languageINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES-
dc.publisherINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnimals-
dc.subject.MESHCell Proliferation-
dc.subject.MESHDNA-Binding Proteins / genetics-
dc.subject.MESHDNA-Binding Proteins / metabolism*-
dc.subject.MESHEmbryo, Mammalian / cytology*-
dc.subject.MESHEmbryo, Mammalian / metabolism-
dc.subject.MESHGene Expression Regulation, Developmental*-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred ICR-
dc.subject.MESHMorphogenesis*-
dc.subject.MESHOdontogenesis*-
dc.subject.MESHRNA-Binding Proteins / genetics-
dc.subject.MESHRNA-Binding Proteins / metabolism*-
dc.subject.MESHSignal Transduction-
dc.subject.MESHTooth / embryology*-
dc.subject.MESHTooth / metabolism-
dc.titleDevelopmental Roles of FUSE Binding Protein 1 ( Fubp1) in Tooth Morphogenesis-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Biology (구강생물학교실)-
dc.contributor.googleauthorYam Prasad Aryal-
dc.contributor.googleauthorSanjiv Neupane-
dc.contributor.googleauthorTae-Young Kim-
dc.contributor.googleauthorEui-Seon Lee-
dc.contributor.googleauthorNitin Kumar Pokhrel-
dc.contributor.googleauthorChang-Yeol Yeon-
dc.contributor.googleauthorJi-Youn Kim-
dc.contributor.googleauthorChang-Hyeon An-
dc.contributor.googleauthorSeo-Young An-
dc.contributor.googleauthorEui-Kyun Park-
dc.contributor.googleauthorJung-Hong Ha-
dc.contributor.googleauthorJae-Kwang Jung-
dc.contributor.googleauthorHitoshi Yamamoto-
dc.contributor.googleauthorSung-Won Cho-
dc.contributor.googleauthorSanggyu Lee-
dc.contributor.googleauthorDo-Yeon Kim-
dc.contributor.googleauthorTae-Yub Kwon-
dc.contributor.googleauthorYoungkyun Lee-
dc.contributor.googleauthorWern-Joo Sohn-
dc.contributor.googleauthorJae-Young Kim-
dc.identifier.doi10.3390/ijms21218079-
dc.contributor.localIdA03837-
dc.relation.journalcodeJ01133-
dc.identifier.eissn1422-0067-
dc.identifier.pmid33138041-
dc.subject.keywordFubp1-
dc.subject.keywordamelogenesis-
dc.subject.keyworddentinogenesis-
dc.subject.keywordtooth development-
dc.subject.keywordtranscriptional regulator-
dc.contributor.alternativeNameCho, Sung Won-
dc.contributor.affiliatedAuthor조성원-
dc.citation.volume21-
dc.citation.number21-
dc.citation.startPage8079-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.21(21) : 8079, 2020-10-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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