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Non-inferiority study of the efficacy of two hyaluronic acid products in post-extraction sockets of impacted third molars

Authors
 Hyunwoo Yang  ;  Junghun Kim  ;  Jihong Kim  ;  Dongwook Kim  ;  Hyung Jun Kim 
Citation
 Maxillofacial Plastic and Reconstructive Surgery, Vol.42(1) : 40, 2020-12 
Journal Title
Maxillofacial Plastic and Reconstructive Surgery
ISSN
 2288-8101 
Issue Date
2020-12
Keywords
Aloclair ; Double blind test ; Hyaluronic acid ; Mandibular third molar ; Mucobarrier
Abstract
Background: Hyaluronic acid (HA) is well known to exert an anti-inflammatory effect during oral wound healing and is commonly applied after tooth extraction. However, no double-blind randomized controlled study comparing two hyaluronate mouthwash products has been conducted so far. The aim of this study was to comparatively analyze the efficacy of Mucobarrier® and Aloclair® in terms of clinical symptoms. Results: A total of 112 patients were randomly assigned to assess the degree of discomfort, pain reduction, redness, burning sensation, and swelling between two groups on the day of surgery and 7 days later in a double blind test, with a total 56 Aloclair patients and 56 Mucobarrier patients. There was no statistically significant difference in the overall discomfort, degree of pain reduction, redness, burning sensation, and swelling between the Mucobarrier and Aloclair groups. Conclusion: The local application of hyaluronic acid mouth wash after wisdom tooth extraction is beneficial in reducing overall discomfort and pain reduction, and the clinical utility of Mucobarrier® is no different from Aloclair®. Trial registration: Institutional Review Board of Yonsei University College of Dentistry, 2-2018-0036. Registered 10 September 2018-prospectively registered, https://eirb.yuhs.ac/.
Files in This Item:
T202006724.pdf Download
DOI
10.1186/s40902-020-00287-y
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Wook(김동욱) ORCID logo https://orcid.org/0000-0001-6167-6475
Kim, Hyung Jun(김형준) ORCID logo https://orcid.org/0000-0001-8247-4004
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182712
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