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The effect of Korean Red Ginseng on sarcopenia biomarkers in type 2 diabetes patients

Authors
 Kahui Park  ;  Chul Woo Ahn  ;  YuSik Kim  ;  Ji Sun Nam 
Citation
 ARCHIVES OF GERONTOLOGY AND GERIATRICS, Vol.90 : 104108, 2020-09 
Journal Title
ARCHIVES OF GERONTOLOGY AND GERIATRICS
ISSN
 0167-4943 
Issue Date
2020-09
MeSH
Aged ; Biomarkers ; Diabetes Mellitus, Type 2* / complications ; Diabetes Mellitus, Type 2* / drug therapy ; Female ; Humans ; Panax* ; Plant Extracts / pharmacology ; Plant Extracts / therapeutic use ; Sarcopenia* / drug therapy
Keywords
Follistatin ; GDF-15 ; Korean red ginseng ; Sarcopenia ; Type 2 diabetes
Abstract
Background: The elderly population is growing rapidly worldwide and sarcopenia, which is considered as a new geriatric syndrome has become an important issue. In particular, diabetes is known to be an important risk factor for sarcopenia. In this study, we investigated the effects of Korean Red Ginseng (KRG) on biomarkers of sarcopenia in middle and old age diabetes patients.

Patients and methods: This study was a randomized, double-blind, placebo-controlled trial. Participants were randomly allocated to either the placebo or KRG group and took corresponding tablets for 24 weeks. The primary outcomes were changes in sarcopenia biomarkers at week 24. Secondary outcomes were changes in inflammatory and antioxidant markers and lean body mass at week 24.

Results: Fifty-nine patients completed the study. Follistatin and sex hormone binding globulin (SHBG) were significantly improved in KRG group. In the subgroup analysis, female postmenopausal patients over the age of 55 showed a significant improvement in serum SHBG, follistatin, and growth differentiation factor 15 (GDF-15) and an attenuated reduction in Troponin T (TNT) after the administration of KRG.

Conclusion: Twenty-four week administration of KRG in diabetes patients resulted in a significant improvement in follistatin and SHBG levels, especially in old postmenopausal women. A further, larger population study with a longer follow-up period is warranted to verify and understand the effects of KRG on sarcopenia.
Full Text
https://www.sciencedirect.com/science/article/pii/S0167494320301023
DOI
10.1016/j.archger.2020.104108
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Nam, Ji Sun(남지선) ORCID logo https://orcid.org/0000-0001-8655-5258
Park, Kahui(박가희)
Ahn, Chul Woo(안철우) ORCID logo https://orcid.org/0000-0003-3733-7486
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182674
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