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Bioinspired DNase-I-Coated Melanin-Like Nanospheres for Modulation of Infection-Associated NETosis Dysregulation
DC Field | Value | Language |
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dc.contributor.author | 권호근 | - |
dc.date.accessioned | 2021-05-21T17:02:17Z | - |
dc.date.available | 2021-05-21T17:02:17Z | - |
dc.date.issued | 2020-10 | - |
dc.identifier.issn | * | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182664 | - |
dc.description.abstract | The current outbreak of the beta-coronavirus (beta-Cov) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in December 2019. No specific antiviral treatments or vaccines are currently available. A recent study has reported that coronavirus disease 2019 (COVID-19), the disease caused by SARS-CoV-2 infection, is associated with neutrophil-specific plasma membrane rupture, and release excessive neutrophil extracellular traps (NETs) and extracellular DNAs (eDNAs). This mechanism involves the activation of NETosis, a neutrophil-specific programmed cell death, which is believed to play a crucial role in COVID-19 pathogenesis. Further progression of the disease can cause uncontrolled inflammation, leading to the initiation of cytokine storms, acute respiratory distress syndrome (ARDS), and sepsis. Herein, it is reported that DNase-I-coated melanin-like nanospheres (DNase-I pMNSs) mitigate sepsis-associated NETosis dysregulation, thereby preventing further progression of the disease. Recombinant DNase-I and poly(ethylene glycol) (PEG) are used as coatings to promote the lengthy circulation and dissolution of NET structure. The data indicate that the application of bioinspired DNase-I pMNSs reduce neutrophil counts and NETosis-related factors in the plasma of SARS-CoV-2 sepsis patients, alleviates systemic inflammation, and attenuates mortality in a septic mouse model. Altogether, the findings suggest that these nanoparticles have potential applications in the treatment of SARS-CoV-2-related illnesses and other beta-CoV-related diseases. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | WILEY-VCH | - |
dc.relation.isPartOf | ADVANCED SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Bioinspired DNase-I-Coated Melanin-Like Nanospheres for Modulation of Infection-Associated NETosis Dysregulation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.googleauthor | Hee Ho Park | - |
dc.contributor.googleauthor | Wooram Park | - |
dc.contributor.googleauthor | Yun Young Lee | - |
dc.contributor.googleauthor | Hyelim Kim | - |
dc.contributor.googleauthor | Hee Seung Seo | - |
dc.contributor.googleauthor | Dong Wook Choi | - |
dc.contributor.googleauthor | Ho-Keun Kwon | - |
dc.contributor.googleauthor | Dong Hee Na | - |
dc.contributor.googleauthor | Tae-Hyung Kim | - |
dc.contributor.googleauthor | Young Bin Choy | - |
dc.contributor.googleauthor | June Hong Ahn | - |
dc.contributor.googleauthor | Wonhwa Lee | - |
dc.contributor.googleauthor | Chun Gwon Park | - |
dc.identifier.doi | 10.1002/advs.202001940 | - |
dc.contributor.localId | A05782 | - |
dc.relation.journalcode | J04017 | - |
dc.identifier.eissn | 2198-3844 | - |
dc.identifier.pmid | 33173718 | - |
dc.subject.keyword | Bioinspiration | - |
dc.subject.keyword | COVID‐19 | - |
dc.subject.keyword | DNase‐I | - |
dc.subject.keyword | NETosis | - |
dc.subject.keyword | Nanospheres | - |
dc.contributor.alternativeName | Kwon, Ho-Keun | - |
dc.contributor.affiliatedAuthor | 권호근 | - |
dc.citation.volume | 7 | - |
dc.citation.number | 23 | - |
dc.citation.startPage | 2001940 | - |
dc.identifier.bibliographicCitation | ADVANCED SCIENCE, Vol.7(23) : 2001940, 2020-10 | - |
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