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Increasing incidence of inflammatory bowel disease in children and adolescents: significance of environmental factors

Authors
 Sowon Park  ;  Yunkoo Kang  ;  Hong Koh  ;  Seung Kim 
Citation
 Clinical and Experimental Pediatrics, Vol.63(9) : 337-344, 2020-09 
Journal Title
Clinical and Experimental Pediatrics
Issue Date
2020-09
Keywords
Diet ; Fecal microbiota transplantation ; Inflammatory bowel disease ; Microbiota
Abstract
Inflammatory bowel disease (IBD) is a chronic relapsing immune-mediated disease of the intestinal tract. Although its prevalence is reportedly lower in Asia than in Western countries, the rapid increase in the incidence of IBD has drawn attention to its etiology, including genetic susceptibility and environmental factors. Specifically, recent studies concerning dietary treatments and intestinal microbiota suggest that these factors may interact with the immune system, and the imbalance of this relationship may lead to immune dysregulation in IBD. Changes in diet or alterations in the composition of the intestinal microbiota may be associated with the increasing incidence of IBD in Asia. Here, we aim to review recent studies on the role of diet and intestinal microbiota in IBD pathogenesis and the results of the investigations performed to modulate these factors.
Files in This Item:
T202006314.pdf Download
DOI
10.3345/cep.2019.00500
Appears in Collections:
1. College of Medicine (의과대학) > Others (기타) > 1. Journal Papers
Yonsei Authors
Koh, Hong(고홍) ORCID logo https://orcid.org/0000-0002-3660-7483
Kim, Seung(김승) ORCID logo https://orcid.org/0000-0003-4373-9828
Park, So Won(박소원) ORCID logo https://orcid.org/0000-0002-2498-8004
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182603
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