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Prognostic Factors and Long-term Surgical Outcomes for Exudative Age-related Macular Degeneration with Breakthrough Vitreous Hemorrhage
DC Field | Value | Language |
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dc.contributor.author | 강현구 | - |
dc.contributor.author | 고형준 | - |
dc.contributor.author | 김민 | - |
dc.contributor.author | 김성수 | - |
dc.contributor.author | 변석호 | - |
dc.contributor.author | 이승규 | - |
dc.contributor.author | 이지환 | - |
dc.contributor.author | 최은영 | - |
dc.date.accessioned | 2021-05-21T16:51:15Z | - |
dc.date.available | 2021-05-21T16:51:15Z | - |
dc.date.issued | 2020-08 | - |
dc.identifier.issn | 1011-8942 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182592 | - |
dc.description.abstract | Purpose: We sought to evaluate the long-term outcomes for patients with exudative age-related macular degeneration (AMD) undergoing vitrectomy for breakthrough vitreous hemorrhage and to investigate possible prognostic factors. Methods: Consecutive patients treated at two high-volume referral-based tertiary hospitals between July 2006 and December 2019 were retrospectively reviewed. Surgery was performed using the standard three-port vitrectomy. The primary outcome was the change in best-corrected visual acuity (BCVA) over long-term follow-up, while secondary outcomes included the assessment of possible prognostic factors. Results: Among 50 eyes from 50 patients included in this study, 23 (46%) were diagnosed with polypoidal choroidal vasculopathy (PCV) and 27 (54%) were diagnosed with neovascular AMD. Preoperative vision at the time of vitreous hemorrhage onset was 20 / 3,027 (logarithm of the minimum angle of resolution [logMAR], 2.18 ± 0.34). At 12 months after surgery, the mean BCVA improved to 20 / 873 (logMAR, 1.64 ± 0.76; p < 0.001). At 24 months, the BCVA was 20 / 853 (logMAR, 1.63 ± 0.75; p < 0.001). Univariate analysis revealed that older age (odds ratio [OR], 0.879; p = 0.007] and the presence of submacular hemorrhage (OR, 0.081; p = 0.022) were factors associated with a poor 2-year visual outcome. Multivariable regression showed that older age (OR, 0.876; p = 0.026) and neovascular AMD (as compared with PCV) (OR, 0.137; p = 0.014) were significant negative factors influencing the 2-year visual outcome. The mean injection interval prior to vitrectomy was 4.53 months, which extended to 27.64 months after vitrectomy (p = 0.028). Conclusions: Younger age, the absence of submacular hemorrhage, and PCV type were associated with a favorable 2-year visual outcome after vitrectomy for vitreous hemorrhage in patients with exudative AMD. Overall, vitrectomy resulted in improved visual acuity and patients showed a decreased need for anti-vascular endothelial growth factor therapy thereafter. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | KJO | - |
dc.relation.isPartOf | Korean Journal of Ophthalmology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Prognostic Factors and Long-term Surgical Outcomes for Exudative Age-related Macular Degeneration with Breakthrough Vitreous Hemorrhage | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Ophthalmology (안과학교실) | - |
dc.contributor.googleauthor | Tae Young Kim | - |
dc.contributor.googleauthor | Hyun Goo Kang | - |
dc.contributor.googleauthor | Eun Young Choi | - |
dc.contributor.googleauthor | Hyoung Jun Koh | - |
dc.contributor.googleauthor | Sung Soo Kim | - |
dc.contributor.googleauthor | Ji Hwan Lee | - |
dc.contributor.googleauthor | Min Kim | - |
dc.contributor.googleauthor | Suk Ho Byeon | - |
dc.contributor.googleauthor | Christopher Seungkyu Lee | - |
dc.identifier.doi | 10.3341/kjo.2020.0014 | - |
dc.contributor.localId | A04873 | - |
dc.contributor.localId | A00152 | - |
dc.contributor.localId | A00455 | - |
dc.contributor.localId | A00571 | - |
dc.contributor.localId | A01849 | - |
dc.contributor.localId | A02913 | - |
dc.contributor.localId | A03222 | - |
dc.contributor.localId | A05056 | - |
dc.relation.journalcode | J02931 | - |
dc.identifier.eissn | 2092-9382 | - |
dc.identifier.pmid | 32783420 | - |
dc.subject.keyword | Macular degeneration | - |
dc.subject.keyword | Prognosis | - |
dc.subject.keyword | Vitrectomy | - |
dc.subject.keyword | Vitreous hemorrhage | - |
dc.contributor.alternativeName | Kang, Hyun Goo | - |
dc.contributor.affiliatedAuthor | 강현구 | - |
dc.contributor.affiliatedAuthor | 고형준 | - |
dc.contributor.affiliatedAuthor | 김민 | - |
dc.contributor.affiliatedAuthor | 김성수 | - |
dc.contributor.affiliatedAuthor | 변석호 | - |
dc.contributor.affiliatedAuthor | 이승규 | - |
dc.contributor.affiliatedAuthor | 이지환 | - |
dc.contributor.affiliatedAuthor | 최은영 | - |
dc.citation.volume | 34 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 281 | - |
dc.citation.endPage | 289 | - |
dc.identifier.bibliographicCitation | Korean Journal of Ophthalmology, Vol.34(4) : 281-289, 2020-08 | - |
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