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Evaluation and Management of Difficult-to-Treat and Severe Asthma: An Expert Opinion From the Korean Academy of Asthma, Allergy and Clinical Immunology, the Working Group on Severe Asthma

 Byung Keun Kim  ;  So Young Park  ;  Ga Young Ban  ;  Mi Ae Kim  ;  Ji Hyang Lee  ;  Jin An  ;  Ji Su Shim  ;  Youngsoo Lee  ;  Ha Kyeong Won  ;  Hwa Young Lee  ;  Kyoung Hee Sohn  ;  Sung Yoon Kang  ;  So Young Park  ;  Hyun Lee  ;  Min Hye Kim  ;  Jae Woo Kwon  ;  Sun Young Yoon  ;  Jae Hyun Lee  ;  Chin Kook Rhee  ;  Ji Yong Moon  ;  Taehoon Lee  ;  So Ri Kim  ;  Jong Sook Park  ;  Sang Heon Kim  ;  Heung Woo Park  ;  Jae Won Jeong  ;  Sang Hoon Kim  ;  Young Il Koh  ;  Yeon Mok Oh  ;  An Soo Jang  ;  Kwang Ha Yoo  ;  You Sook Cho 
 ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, Vol.12(6) : 910-933, 2020-11 
Journal Title
Issue Date
IL4 ; IgE ; Severe asthma ; biologics ; diagnosis ; eosinophil ; expert opinion ; treatment, IL5
Severe asthma (SA) presents in about 3%-5% of adult asthmatics and is responsible for over 60% of asthma-related medical expenses, posing a heavy socioeconomic burden. However, to date, a precise definition of or clear diagnostic criteria for SA have not been established, and therefore, it has been challenging for clinicians to diagnose and treat this disease. Currently, novel biologics targeting several molecules, such as immunoglobulin E, interleukin (IL)5, and IL4/IL13, have emerged, and many new drugs are under development. These have brought a paradigm shift in understanding the mechanism of SA and have also provided new treatment options. However, we need to agree on a precise definition of and its diagnostic criteria for SA. Additionally, it is necessary to explain the diagnostic criteria and to summarize current standard and additional treatment options. This review is an experts' opinion on SA from the Korean Academy of Asthma, Allergy, and Clinical Immunology, the Working Group on Severe Asthma, and aims to provide a definition of and diagnostic criteria for SA, and propose future direction for SA diagnosis and management in Korea.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Jae Hyun(이재현) ORCID logo https://orcid.org/0000-0002-0760-0071
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