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A multicenter anaphylaxis registry in Korea: Clinical characteristics and acute treatment details from infants to older adults

 Kyunguk Jeong  ;  Young-Min Ye  ;  Sang-Ha Kim  ;  Kyung Won Kim  ;  Jeong Hee Kim  ;  Ji-Won Kwon  ;  Song-I Yang  ;  So-Yeon Lee  ;  Eun Hee Chung  ;  Mi-Ae Kim  ;  Yoon Hee Kim  ;  Hye-Young Kim  ;  Gwang Cheon Jang  ;  Joo-Hee Kim  ;  Eunjoo Lee  ;  Jihyun Kim  ;  Kangmo Ahn  ;  Yoon-Seok Chang  ;  Gyu-Young Hur  ;  Jeongmin Lee  ;  Taek Ki Min  ;  Bok-Yang Pyun  ;  Kyung Hee Park  ;  Jaechun Lee  ;  Tae Won Song  ;  Hye Mi Jee  ;  Yoo Seob Shin  ;  Dankyu Yoon  ;  Jeom-Kyu Lee  ;  Sooyoung Lee 
 WORLD ALLERGY ORGANIZATION JOURNAL, Vol.13(8) : 100449, 2020-08 
Journal Title
Issue Date
Anaphylaxis ; CRF, case report form ; ED, emergency department ; Epinephrine ; FDEIA, food-dependent exercise-induced anaphylaxis ; OPD, outpatient department ; Registry ; Severity ; Trigger
Background: Although the prevalence of anaphylaxis is increasing worldwide, the large-scale studies in Asia evaluating anaphylaxis in all age groups are limited. We aimed to collect more precise and standardized data on anaphylaxis in Korea using the first multicenter web-based registry.

Methods: Twenty-two departments from 16 hospitals participated from November 2016 to December 2018. A web-based case report form, designed by allergy specialists, was used to collect anaphylaxis data.

Results: Within the 2-year period, 558 anaphylaxis cases were registered. The age of registered patients ranged from 2 months to 84 years, and 60% were aged <18 years. In children and adolescents, foods (84.8%) were the most common cause of anaphylaxis, followed by drugs (7.2%); in adults, drugs (58.3%) were the most common cause, followed by foods (28.3%) and insect venom (8.1%). The onset time was ≤10 min in 37.6% of patients. Among the 351 cases registered via the emergency department (ED) of participating hospitals, epinephrine was administered to 63.8% of patients. Among those receiving epinephrine in the ED, 13.8% required 2 or more epinephrine shots. Severe anaphylaxis accounted for 23.5% cases (38.1% in adults; 13.7% in children); patients with drug and insect venom-induced anaphylaxis had higher rates of severe anaphylaxis.

Conclusion: This multicenter registry provides data on anaphylaxis for all age groups for the first time in Asia. The major causes and severity of anaphylaxis were remarkably different according to age group, and the acute treatment features of anaphylaxis in the EDs were examined in detail.
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1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
Kim, Yoon Hee(김윤희) ORCID logo https://orcid.org/0000-0002-2149-8501
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