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Cross-Sectional Association between Hypercholesterolemia and Knee Pain in the Elderly with Radiographic Knee Osteoarthritis: Data from the Korean National Health and Nutritional Examination Survey

Authors
 Byung Woo Cho  ;  Du Seong Kim  ;  Hyuck Min Kwon  ;  Ick Hwan Yang  ;  Woo-Suk Lee  ;  Kwan Kyu Park 
Citation
 JOURNAL OF CLINICAL MEDICINE, Vol.10(5) : 933, 2021-03 
Journal Title
 JOURNAL OF CLINICAL MEDICINE 
Issue Date
2021-03
Keywords
hypercholesterolemia ; knee pain ; metabolic disease ; osteoarthritis
Abstract
Few studies have reported the relationship between knee pain and hypercholesterolemia in the elderly population with osteoarthritis (OA), independent of other variables. The aim of this study was to reveal the association between knee pain and metabolic diseases including hypercholesterolemia using a large-scale cohort. A cross-sectional study was conducted using data from the Korea National Health and the Nutrition Examination Survey (KNHANES-V, VI-1; 2010-2013). Among the subjects aged ≥60 years, 7438 subjects (weighted number estimate = 35,524,307) who replied knee pain item and performed the simple radiographs of knee were enrolled. Using multivariable ordinal logistic regression analysis, variables affecting knee pain were identified, and the odds ratio (OR) was calculated. Of the 35,524,307 subjects, 10,630,836 (29.9%) subjects experienced knee pain. Overall, 20,290,421 subjects (56.3%) had radiographic OA, and 8,119,372 (40.0%) of them complained of knee pain. Multivariable ordinal logistic regression analysis showed that among the metabolic diseases, only hypercholesterolemia was positively correlated with knee pain in the OA group (OR 1.24; 95% Confidence Interval 1.02-1.52, p = 0.033). There were no metabolic diseases correlated with knee pain in the non-OA group. This large-scale study revealed that in the elderly, hypercholesterolemia was positively associated with knee pain independent of body mass index and other metabolic diseases in the OA group, but not in the non-OA group. These results will help in understanding the nature of arthritic pain, and may support the need for exploring the longitudinal associations.
Files in This Item:
T202101168.pdf Download
DOI
10.3390/jcm10050933
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Hyuck Min(권혁민) ORCID logo https://orcid.org/0000-0002-2924-280X
Park, Kwan Kyu(박관규) ORCID logo https://orcid.org/0000-0003-0514-3257
Yang, Ick Hwan(양익환)
Lee, Woo Suk(이우석) ORCID logo https://orcid.org/0000-0002-0798-1660
Cho, Byung Woo(조병우) ORCID logo https://orcid.org/0000-0002-7472-4103
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182413
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