Cited 13 times in
Activation of KCNQ4 as a Therapeutic Strategy to Treat Hearing Loss
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 임정훈 | - |
dc.contributor.author | 정진세 | - |
dc.contributor.author | 지헌영 | - |
dc.contributor.author | 최재영 | - |
dc.date.accessioned | 2021-04-29T17:33:01Z | - |
dc.date.available | 2021-04-29T17:33:01Z | - |
dc.date.issued | 2021-03 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182404 | - |
dc.description.abstract | Potassium voltage-gated channel subfamily q member 4 (KCNQ4) is a voltage-gated potassium channel that plays essential roles in maintaining ion homeostasis and regulating hair cell membrane potential. Reduction of the activity of the KCNQ4 channel owing to genetic mutations is responsible for nonsyndromic hearing loss, a typically late-onset, initially high-frequency loss progressing over time. In addition, variants of KCNQ4 have also been associated with noise-induced hearing loss and age-related hearing loss. Therefore, the discovery of small compounds activating or potentiating KCNQ4 is an important strategy for the curative treatment of hearing loss. In this review, we updated the current concept of the physiological role of KCNQ4 in the inner ear and the pathologic mechanism underlying the role of KCNQ4 variants with regard to hearing loss. Finally, we focused on currently developed KCNQ4 activators and their pros and cons, paving the way for the future development of specific KCNQ4 activators as a remedy for hearing loss. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.publisher | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Activation of KCNQ4 as a Therapeutic Strategy to Treat Hearing Loss | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학교실) | - |
dc.contributor.googleauthor | John Hoon Rim | - |
dc.contributor.googleauthor | Jae Young Choi | - |
dc.contributor.googleauthor | Jinsei Jung | - |
dc.contributor.googleauthor | Heon Yung Gee | - |
dc.identifier.doi | 10.3390/ijms22052510 | - |
dc.contributor.localId | A04654 | - |
dc.contributor.localId | A03742 | - |
dc.contributor.localId | A03971 | - |
dc.contributor.localId | A04173 | - |
dc.relation.journalcode | J01133 | - |
dc.identifier.eissn | 1422-0067 | - |
dc.identifier.pmid | 33801540 | - |
dc.subject.keyword | KCNQ4 activator | - |
dc.subject.keyword | hearing loss | - |
dc.subject.keyword | nonsyndromic hearing loss | - |
dc.subject.keyword | potassium | - |
dc.subject.keyword | potassium voltage-gated channel subfamily q member 4 | - |
dc.contributor.alternativeName | Rim, John Hoon | - |
dc.contributor.affiliatedAuthor | 임정훈 | - |
dc.contributor.affiliatedAuthor | 정진세 | - |
dc.contributor.affiliatedAuthor | 지헌영 | - |
dc.contributor.affiliatedAuthor | 최재영 | - |
dc.citation.volume | 22 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 2510 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.22(5) : 2510, 2021-03 | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.