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The Behavioral Effects of Combination Therapy of Memantine and Acetylcholinesterase Inhibitors Compared with Acetylcholinesterase Inhibitors Alone in Patients with Moderate Alzheimer's Dementia: A Double-Blind Randomized Placebo-Controlled Trial

Authors
 HyunChul Youn  ;  Kang Joon Lee  ;  Shin-Gyeom Kim  ;  Seong-Jin Cho  ;  Woo Jung Kim  ;  Won Joon Lee  ;  Jae Yeon Hwang  ;  Changsu Han  ;  Cheolmin Shin  ;  Han-Yong Jung 
Citation
 PSYCHIATRY INVESTIGATION, Vol.18(3) : 233-240, 2021-03 
Journal Title
 PSYCHIATRY INVESTIGATION 
ISSN
 1738-3684 
Issue Date
2021-03
Keywords
Acetylcholinesterase inhibitors ; Alzheimer’s dementia ; Behavioral and psychological symptoms of dementia ; Disinhibition ; Memantine ; Neuropsychiatric inventory
Abstract
Objective: This study aimed to investigate treatment effects of combination therapy of memantine and acetylcholinesterase inhibitors (AchEIs) compared with AchEIs alone on behavioral and psychological symptoms of dementia (BPSD) in patients with moderate Alzheimer's dementia (AD). Methods: This was a 12-week, double-blind, randomized, placebo-controlled trial. A total of 148 patients with moderate AD participated in this study. Mini-Mental State Examination, Neuropsychiatric Inventory (NPI), Clinician's Interview-Based Impression of Change plus caregiver input, Gottfries-Bråne-Steen Scale, and Zarit Burden Interview were used as assessment scales. Results: There were no significant differences in age, sex, or education between AChEIs alone and combination groups. The combination group showed significantly more improvement of NPI-disinhibition score (0.76±2.15) than the AChEIs alone group (-0.14±1.71) after 12 weeks. Conclusion: Our findings suggest that the combination therapy of memantine and AchEIs might be a beneficial option for reducing disinhibition symptoms of patients with moderate AD compared with AchEIs alone. We believe that clinicians need to consider additional memantine treatment when patients with moderate AD complain disinhibition symptom. A larger clinical trial is needed to further determine the efficacy and advantages of such combination therapy of memantine and AchEIs for treating BPSD of patients with moderate AD.
Files in This Item:
T202101132.pdf Download
DOI
10.30773/pi.2020.0329
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Woo Jung(김우정) ORCID logo https://orcid.org/0000-0002-4963-4819
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182395
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