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Risk and protective factors for mental disorders with onset in childhood/adolescence: An umbrella review of published meta-analyses of observational longitudinal studies

Authors
 Marco Solmi  ;  Elena Dragioti  ;  Celso Arango  ;  Joaquim Radua  ;  Edoardo Ostinelli  ;  Ozge Kilic  ;  Ugur Eser Yilmaz  ;  Merve Yalcinay-İnan  ;  Fernanda Cunha Soares  ;  Luca Mariano  ;  Pierluca Mosillo  ;  Samuele Cortese  ;  Christoph U Correll  ;  Andre F Carvalho  ;  Jae Il Shin  ;  Paolo Fusar-Poli 
Citation
 NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, Vol.120 : 565-573, 2021-01 
Journal Title
 NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS 
ISSN
 0149-7634 
Issue Date
2021-01
Keywords
Adolescence ; Childhood ; Mental health ; Meta-analysis ; Neurodevelopmental ; Prevention ; Risk factor ; Systematic review ; umbrella review
Abstract
The patho-etiology of mental disorders with onset in childhood or adolescence remains largely unknown. We conducted an umbrella review of meta-analyses (MAs) on environmental factors associated with mental disorders with onset in childhood/adolescence. We searched Pubmed-MEDLINE/EMBASE/PsycInfo databases, last search April 29th, 2020. Quality of MAs was measured with AMSTAR-2. Out of 6851 initial references, ten articles met inclusion criteria, providing 23 associations between 12 potential environmental factors and nine disorders (cases: 8884; N = 3,660,670). While almost half of the associations were nominally significant, none of them met criteria from either convincing or highly suggestive evidence. A single association was supported by suggestive evidence (maternal exposure to lithium or antipsychotics with neuromotor deficits), but it was affected by confounding by indication. Ten more associations had weak evidence, and 12 associations were not statistically significant. Quality of meta-analyses was rated as high in two, moderate in one, low in four, critically low in two, and not pertinent in one (individual participant data). Methodologically-sound research is needed in this field.
Full Text
https://www.sciencedirect.com/science/article/pii/S0149763420305601
DOI
10.1016/j.neubiorev.2020.09.002
Appears in Collections:
1. College of Medicine (의과대학) > Others (기타) > 1. Journal Papers
Yonsei Authors
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182385
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