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A case of fatal intoxication by ingestion of an herbicide formulation containing fluroxypyr-meptyl and triclopyr

Authors
 Moonhee Jang  ;  Dongwoo Kim  ;  Hyesun Yum  ;  Sungmin Moon  ;  Minji Kang  ;  Byungjoo Kim  ;  Jong-Pil Park  ;  Sanggil Choe 
Citation
 FORENSIC SCIENCE INTERNATIONAL, Vol.320 : 110717, 2021-03 
Journal Title
 FORENSIC SCIENCE INTERNATIONAL 
ISSN
 0379-0738 
Issue Date
2021-03
Keywords
Blood ; Fluroxypyr ; Fluroxypyr-meptyl ; Intoxication ; Liquid chromatography–tandem mass spectrometry ; Triclopyr
Abstract
Fluroxypyr-meptyl and triclopyr are synthetic auxin-like herbicides that are used to control woody and broadleaf weeds. Herein, we report a case of fatal intoxication involving fluroxypyr-meptyl and triclopyr. A 61-year-old man was found dead at his farm with several suicide notes, and a white plastic bottle and a plastic cup with traces of white emulsion were found next to him. The plastic bottle was labeled as an herbicide formulation containing fluroxypyr-meptyl and triclopyr. Forensic toxicological screening of the stomach contents revealed the presence of fluroxypyr-meptyl, fluroxypyr and triclopyr. However, no fluroxypyr-meptyl was detected in blood owing to its rapid hydrolysis to fluroxypyr. In this study, fluroxypyr and triclopyr in blood were extracted using solid-phase extraction, and analyzed by liquid chromatography-tandem mass spectrometry. The analytical method was validated in terms of linearity, precision, accuracy, recovery and matrix effect, and the acceptable criteria were satisfied. Toxicological analysis showed that fluroxypyr and triclopyr concentrations were 19.7 μg/mL and 137.4 μg/mL in peripheral blood and 16.5 μg/mL and 147.8 μg/mL in heart blood, respectively. Based on these toxicological results and autopsy findings, the cause of death was determined to be acute fatal intoxication by ingestion of the pesticide containing fluroxypyr-meptyl and triclopyr. This is the first report of the determination of fluroxypyr and triclopyr in a fatal intoxication case.
Full Text
https://www.sciencedirect.com/science/article/pii/S0379073821000372
DOI
10.1016/j.forsciint.2021.110717
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Forensic Medicine (법의학과) > 1. Journal Papers
Yonsei Authors
Park, Jong Pil(박종필) ORCID logo https://orcid.org/0000-0002-6525-3012
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182380
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