Cited 4 times in
Environmental Enrichment Enhances Cav 2.1 Channel-Mediated Presynaptic Plasticity in Hypoxic–Ischemic Encephalopathy
DC Field | Value | Language |
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dc.contributor.author | 조성래 | - |
dc.date.accessioned | 2021-04-29T17:26:30Z | - |
dc.date.available | 2021-04-29T17:26:30Z | - |
dc.date.issued | 2021-04 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182342 | - |
dc.description.abstract | Hypoxic-ischemic encephalopathy (HIE) is a devastating neonatal brain condition caused by lack of oxygen and limited blood flow. Environmental enrichment (EE) is a classic paradigm with a complex stimulation of physical, cognitive, and social components. EE can exert neuroplasticity and neuroprotective effects in immature brains. However, the exact mechanism of EE on the chronic condition of HIE remains unclear. HIE was induced by a permanent ligation of the right carotid artery, followed by an 8% O2 hypoxic condition for 1 h. At 6 weeks of age, HIE mice were randomly assigned to either standard cages or EE cages. In the behavioral assessments, EE mice showed significantly improved motor performances in rotarod tests, ladder walking tests, and hanging wire tests, compared with HIE control mice. EE mice also significantly enhanced cognitive performances in Y-maze tests. Particularly, EE mice showed a significant increase in Cav 2.1 (P/Q type) and presynaptic proteins by molecular assessments, and a significant increase of Cav 2.1 in histological assessments of the cerebral cortex and hippocampus. These results indicate that EE can upregulate the expression of the Cav 2.1 channel and presynaptic proteins related to the synaptic vesicle cycle and neurotransmitter release, which may be responsible for motor and cognitive improvements in HIE. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.publisher | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Calcium Channels, N-Type / metabolism* | - |
dc.subject.MESH | Cerebral Cortex / metabolism | - |
dc.subject.MESH | Cognition | - |
dc.subject.MESH | Environment* | - |
dc.subject.MESH | Hippocampus / metabolism | - |
dc.subject.MESH | Hypoxia-Ischemia, Brain / metabolism* | - |
dc.subject.MESH | Hypoxia-Ischemia, Brain / physiopathology | - |
dc.subject.MESH | Hypoxia-Ischemia, Brain / therapy | - |
dc.subject.MESH | Locomotion | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred ICR | - |
dc.subject.MESH | Neuronal Plasticity* | - |
dc.subject.MESH | Perception* | - |
dc.subject.MESH | Spatial Learning | - |
dc.title | Environmental Enrichment Enhances Cav 2.1 Channel-Mediated Presynaptic Plasticity in Hypoxic–Ischemic Encephalopathy | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Rehabilitation Medicine (재활의학교실) | - |
dc.contributor.googleauthor | Suk-Young Song | - |
dc.contributor.googleauthor | Soonil Pyo | - |
dc.contributor.googleauthor | Sungchul Choi | - |
dc.contributor.googleauthor | Hee Sang Oh | - |
dc.contributor.googleauthor | Jung Hwa Seo | - |
dc.contributor.googleauthor | Ji Hea Yu | - |
dc.contributor.googleauthor | Ahreum Baek | - |
dc.contributor.googleauthor | Yoon-Kyum Shin | - |
dc.contributor.googleauthor | Hoo Young Lee | - |
dc.contributor.googleauthor | Ja Young Choi | - |
dc.contributor.googleauthor | Sung-Rae Cho | - |
dc.identifier.doi | 10.3390/ijms22073414 | - |
dc.contributor.localId | A03831 | - |
dc.relation.journalcode | J01133 | - |
dc.identifier.eissn | 1422-0067 | - |
dc.identifier.pmid | 33810296 | - |
dc.subject.keyword | calcium channels | - |
dc.subject.keyword | environmental enrichment | - |
dc.subject.keyword | hypoxic–ischemic encephalopathy | - |
dc.subject.keyword | synaptic plasticity | - |
dc.contributor.alternativeName | Cho, Sung Rae | - |
dc.contributor.affiliatedAuthor | 조성래 | - |
dc.citation.volume | 22 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 3414 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.22(7) : 3414, 2021-04 | - |
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