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Disease progression modelling from preclinical Alzheimer's disease (AD) to AD dementia

Authors
 Soo Hyun Cho  ;  Sookyoung Woo  ;  Changsoo Kim  ;  Hee Jin Kim  ;  Hyemin Jang  ;  Byeong C Kim  ;  Si Eun Kim  ;  Seung Joo Kim  ;  Jun Pyo Kim  ;  Young Hee Jung  ;  Samuel Lockhart  ;  Rik Ossenkoppele  ;  Susan Landau  ;  Duk L Na  ;  Michael Weiner  ;  Seonwoo Kim  ;  Sang Won Seo 
Citation
 SCIENTIFIC REPORTS, Vol.11(1) : 4168, 2021-02 
Journal Title
 SCIENTIFIC REPORTS 
Issue Date
2021-02
Abstract
To characterize the course of Alzheimer's disease (AD) over a longer time interval, we aimed to construct a disease course model for the entire span of the disease using two separate cohorts ranging from preclinical AD to AD dementia. We modelled the progression course of 436 patients with AD continuum and investigated the effects of apolipoprotein E ε4 (APOE ε4) and sex on disease progression. To develop a model of progression from preclinical AD to AD dementia, we estimated Alzheimer's Disease Assessment Scale-Cognitive Subscale 13 (ADAS-cog 13) scores. When calculated as the median of ADAS-cog 13 scores for each cohort, the estimated time from preclinical AD to MCI due to AD was 7.8 years and preclinical AD to AD dementia was 15.2 years. ADAS-cog 13 scores deteriorated most rapidly in women APOE ε4 carriers and most slowly in men APOE ε4 non-carriers (p < 0.001). Our results suggest that disease progression modelling from preclinical AD to AD dementia may help clinicians to estimate where patients are in the disease course and provide information on variation in the disease course by sex and APOE ε4 status.
Files in This Item:
T202100897.pdf Download
DOI
10.1038/s41598-021-83585-3
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chang Soo(김창수) ORCID logo https://orcid.org/0000-0002-5940-5649
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182283
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