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Advances in Management of Intestinal Behçet’s Disease: A Perspective From Gastroenterologists

Authors
 Jae Hee Cheon 
Citation
 Journal of Rheumatic Diseases, Vol.28(1) : 4-16, 2021-01 
Journal Title
 Journal of Rheumatic Diseases 
ISSN
 2093-940X 
Issue Date
2021-01
Keywords
Behet’s disease ; Intestinal Behet’s disease ; Therapeutic strategy ; Anti-TNF-α inhibitor
Abstract
Intestinal Behçet’s disease (intestinal BD) is a rare chronic inflammatory disorder of the intestine that is characterized by recurrent intestinal manifestations with other systemic features of BD. Intestinal BD is diagnosed when a typically shaped ulcer is observed in the gastrointestinal tract, and the clinical findings meet the diagnostic criteria for BD. Owing to the small number of patients, intestinal BD is easily underestimated. On the other hand, but it often requires surgical treatment because of severe complications, including intestinal perforations or massive bleeding. The same treatment strategies used for inflammatory bowel diseases, such as Crohn’s disease and ulcerative colitis, are used for intestinal BD. 5-Aminosalicylic acids, corticosteroids, and immunomodulators are considered conventional therapies, but a considerable number of patients eventually become unresponsive to these pharmaceutical treatments. Recently, biologic agents, such as anti-tumor necrosis factor-alpha inhibitors, have also been suggested as a new treatment option for intestinal BD. This article reviews the pathogenesis and diagnosis of intestinal BD and the current treatment strategies that are expected to be useful for rheumatologic specialists.
Files in This Item:
T202100875.pdf Download
DOI
10.4078/jrd.2021.28.1.4
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Cheon, Jae Hee(천재희) ORCID logo https://orcid.org/0000-0002-2282-8904
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182266
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