Cited 5 times in
Cholesterol Efflux and Collateral Circulation in Chronic Total Coronary Occlusion: Effect-Circ Study
DC Field | Value | Language |
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dc.contributor.author | 강석민 | - |
dc.contributor.author | 박성하 | - |
dc.contributor.author | 오재원 | - |
dc.contributor.author | 이상학 | - |
dc.contributor.author | 이선화 | - |
dc.contributor.author | 이찬주 | - |
dc.date.accessioned | 2021-04-29T17:10:04Z | - |
dc.date.available | 2021-04-29T17:10:04Z | - |
dc.date.issued | 2021-02 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/182214 | - |
dc.description.abstract | Background The mechanism through which high-density lipoprotein (HDL) induces cardioprotection is not completely understood. We evaluated the correlation between cholesterol efflux capacity (CEC), a functional parameter of HDL, and coronary collateral circulation (CCC). We additionally investigated whether A1BP (apoA1-binding protein) concentration correlates with CEC and CCC. Methods and Results In this case-control study, clinical and angiographic data were collected from 226 patients (mean age, 58 years; male, 72%) with chronic total coronary occlusion. CEC was assessed using a radioisotope and J774 cells, and human A1BP concentration was measured using enzyme-linked immunosorbent assay. Differences between the good and poor CCC groups were compared, and associations between CEC, A1BP, and other variables were evaluated. Predictors of CCC were identified by multivariable logistic regression analysis. The CEC was higher in the good than in the poor CCC group (22.0±4.6% versus 20.2±4.7%; P=0.009). In multivariable analyses including age, sex, HDL-cholesterol levels, age (odds ratio [OR], 0.96; P=0.003), and CEC (OR, 1.10; P=0.004) were identified as the independent predictors of good CCC. These relationships remained significant after additional adjustment for diabetes mellitus, acute coronary syndrome, and Gensini score. The A1BP levels were not significantly correlated with CCC (300 pg/mL and 283 pg/mL in the good CCC and poor CCC groups, respectively, P=0.25) or CEC. Conclusions The relationship between higher CEC and good CCC indicates that well-functioning HDL may contribute to CCC and may be cardioprotective; this suggests that a specific function of HDL can have biological and clinical consequences. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Wiley-Blackwell | - |
dc.relation.isPartOf | JOURNAL OF THE AMERICAN HEART ASSOCIATION | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Cholesterol Efflux and Collateral Circulation in Chronic Total Coronary Occlusion: Effect-Circ Study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | Seonhwa Lee | - |
dc.contributor.googleauthor | Jung Mi Park | - |
dc.contributor.googleauthor | Soo-Jin Ann | - |
dc.contributor.googleauthor | Moonjong Kang | - |
dc.contributor.googleauthor | Eun Jeong Cheon | - |
dc.contributor.googleauthor | Dan Bi An | - |
dc.contributor.googleauthor | Yu Ri Choi | - |
dc.contributor.googleauthor | Chan Joo Lee | - |
dc.contributor.googleauthor | Jaewon Oh | - |
dc.contributor.googleauthor | Sungha Park | - |
dc.contributor.googleauthor | Seok-Min Kang | - |
dc.contributor.googleauthor | Sang-Hak Lee | - |
dc.identifier.doi | 10.1161/JAHA.120.019060 | - |
dc.contributor.localId | A00037 | - |
dc.contributor.localId | A01512 | - |
dc.contributor.localId | A02395 | - |
dc.contributor.localId | A02833 | - |
dc.contributor.localId | A05932 | - |
dc.contributor.localId | A03238 | - |
dc.relation.journalcode | J01774 | - |
dc.identifier.eissn | 2047-9980 | - |
dc.identifier.pmid | 33634702 | - |
dc.subject.keyword | apolipoprotein A‐1 | - |
dc.subject.keyword | coronary artery disease | - |
dc.subject.keyword | lipoproteins | - |
dc.subject.keyword | macrophages | - |
dc.contributor.alternativeName | Kang, Seok Min | - |
dc.contributor.affiliatedAuthor | 강석민 | - |
dc.contributor.affiliatedAuthor | 박성하 | - |
dc.contributor.affiliatedAuthor | 오재원 | - |
dc.contributor.affiliatedAuthor | 이상학 | - |
dc.contributor.affiliatedAuthor | 이선화 | - |
dc.contributor.affiliatedAuthor | 이찬주 | - |
dc.citation.volume | 10 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | e019060 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN HEART ASSOCIATION, Vol.10(5) : e019060, 2021-02 | - |
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