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The synergistic effect of focused ultrasound and biophotonics to overcome the barrier of light transmittance in biological tissue

Authors
 Jaehyuk Kim  ;  Jaewoo Shin  ;  Chanho Kong  ;  Sung-Ho Lee  ;  Won Seok Chang  ;  Seung Hee Han 
Citation
 PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, Vol.33 : 102173, 2021-03 
Journal Title
 PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY 
ISSN
 1572-1000 
Issue Date
2021-03
Keywords
Air bubble ; Focused Ultrasound ; Light transmission enhancement ; Mechanical deformation ; Rat brain
Abstract
Optical technology is a tool to diagnose and treat human diseases. Shallow penetration depth caused by the high optical scattering nature of biological tissues is a significant obstacle to utilizing light in the biomedical field. In this paper, light transmission enhancement in the rat brain induced by focused ultrasound (FUS) was observed and the cause of observed enhancement was analyzed. Both air bubbles and mechanical deformation generated by FUS were cited as the cause. The Monte Carlo simulation was performed to investigate effects on transmission by air bubbles and finite element method was also used to describe mechanical deformation induced by motions of acoustic particles. As a result, it was found that the mechanical deformation was more suitable to describe the transmission change according to the FUS pulse observed in the experiment.
Files in This Item:
T202100486.pdf Download
DOI
10.1016/j.pdpdt.2020.102173
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Jaewoo(신재우) ORCID logo https://orcid.org/0000-0002-6335-1292
Chang, Won Seok(장원석) ORCID logo https://orcid.org/0000-0003-3145-4016
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182141
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