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Large-Area, High-Resolution Birefringence Imaging with Polarization-Sensitive Fourier Ptychographic Microscopy

Authors
 Seungri Song  ;  Jeongsoo Kim  ;  Sunwoong Hur  ;  Jaewoo Song  ;  Chulmin Joo 
Citation
 ACS PHOTONICS, Vol.8(1) : 158-165, 2021-01 
Journal Title
 ACS PHOTONICS 
Issue Date
2021-01
Keywords
polarization ; birefringence ; optical anisotropy ; computational imaging ; Fourier ptychographic microscopy
Abstract
We present polarization-sensitive Fourier ptychographic microscopy (PS-FPM) capable of generating high-resolution birefringence images of optically anisotropic specimens over a large field of view (FoV). FPM produces high-resolution images of transparent samples over a large FoV based on multiple intensity measurements acquired at various illumination angles and ptychographic phase retrieval. We combine this attractive feature of FPM with a single-input-state illumination and polarization-diverse imaging system to achieve the imaging of both complex and birefringence information on transparent objects. Compared to conventional polarization imaging techniques, PS-FPM does not involve any mechanical rotation of the polarizer/analyzer and achieves birefringence imaging with a half-pitch resolution of 0.55 μm over 3.78 mm2 FoV, which corresponds to the space-bandwidth product of 12.5 megapixels. We demonstrate the high-resolution, large-area birefringence imaging capability of PS-FPM by presenting the birefringence images of various anisotropic objects including monosodium urate, Tilia stem, and hemozoin crystals.
Full Text
https://pubs.acs.org/doi/10.1021/acsphotonics.0c01695
DOI
10.1021/acsphotonics.0c01695
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Song, Jae Woo(송재우) ORCID logo https://orcid.org/0000-0002-1877-5731
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182055
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