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Body mass index and mortality in patients with cardiovascular disease: an umbrella review of meta-analyses

Authors
 R Abou Ghayda  ;  D Duck-Young Park  ;  J Y Lee  ;  J Y Kim  ;  K H Lee  ;  S H Hong  ;  J W Yang  ;  J S Kim  ;  G H Jeong  ;  A Kronbichler  ;  A Koyanagi  ;  L Jacob  ;  H Oh  ;  H Li  ;  J M Yang  ;  M S Kim  ;  S W Lee  ;  D K Yon  ;  J I Shin  ;  L Smith 
Citation
 EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, Vol.25(1) : 273-286, 2021-01 
Journal Title
 EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES 
ISSN
 1128-3602 
Issue Date
2021-01
Abstract
Objective: Although many previous meta-analyses of epidemiological studies have demonstrated a relationship between body mass index (BMI) and mortality, inconsistent findings among cardiovascular disease patients have been observed. Thus, we performed an umbrella review to understand the strength of evidence and validity of claimed associations between BMI and mortality in patients with cardiovascular diseases. Materials and methods: We comprehensively re-analyzed the data of meta-analyses of observational studies and randomized controlled trials on associations between BMI and mortality among patients with cardiovascular diseases. We also assessed the strength of evidence of the re-analyzed outcomes, which were determined from the criteria including statistical significance of the p-value of random-effects, as well as fixed-effects meta-analyses, small-study effects, between-study heterogeneity, and a 95% prediction interval. Results: We ran comprehensive re-analysis of the data from the 21 selected studies, which contained a total of 108 meta-analyses; 23 were graded as convincing evidence and 12 were suggestive, 42 were weak, and 23 were non-significant. Conclusions: Underweight increased mortality in acute coronary syndrome (ACS), heart failure, and after therapeutic intervention for patients with cardiovascular diseases. Overweight, on the other hand decreased mortality in patient's ACS, atrial fibrillation, and heart failure with convincing evidence.
Files in This Item:
T202100206.pdf Download
DOI
10.26355/eurrev_202101_24393
Appears in Collections:
1. College of Medicine (의과대학) > Others (기타) > 1. Journal Papers
Yonsei Authors
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
Lee, Keum Hwa(이금화) ORCID logo https://orcid.org/0000-0002-1511-9587
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/182019
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