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Immediate versus delayed application of bone morphogenetic protein-2 solution in damaged extraction sockets: a preclinical in vivo investigation

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dc.contributor.author송영우-
dc.contributor.author정의원-
dc.contributor.author차재국-
dc.date.accessioned2021-04-29T16:44:55Z-
dc.date.available2021-04-29T16:44:55Z-
dc.date.issued2021-01-
dc.identifier.issn1432-6981-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/181996-
dc.description.abstractObjective: To compare the clinical, radiographic, and histological healing patterns between the immediate and delayed applications of bone morphogenetic protein-2 (BMP-2) in damaged extraction sockets in dogs. Materials and methods: The distal roots of the fourth premolars of the mandible were extracted bilaterally in five beagle dogs, and buccal bone defects (4 mm wide and 9 mm high) were surgically created. Collagenated biphasic calcium phosphate (CBCP) soaked for 10 min in 100 μL of BMP-2 solution was applied immediately to the defect site in the control group. In the test group, the BMP-2 solution of same dose was injected into the grafted site 2 weeks after grafting with a saline-soaked CBCP. The dogs were sacrificed 2 weeks later. Clinical, histological, and radiographic analyses were followed. Results: Swelling and inflammatory reactions were predominantly observed in the control group at 2 weeks. The area of new bone formation was significantly larger in the control group compared with the test group (10.8 ± 7.0 mm2 [mean ± SD] and 6.3 ± 3.1 mm2, respectively; p = 0.043). No significant difference was found in ridge width at 2 mm, 4 mm and 6 mm below the lingual bone crest between the control (2.6 ± 1.0 mm, 3.2 ± 0.9 mm and 4.5 ± 0.5 mm, respectively) and test group (3.3 ± 1.0 mm, 3.7 ± 1.3 mm and 4.2 ± 1.0 mm; all p > 0.05). Conclusions: Delayed application of BMP-2 2 weeks after surgery did not show any advantage over immediate application of BMP-2 in terms of new bone formation. Clinical relevance: This study suggests that it might be better to apply BMP-2 immediately in alveolar ridge preservation, instead of delayed application, in order to enhance new bone formation.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer-Verlag-
dc.relation.isPartOfCLINICAL ORAL INVESTIGATIONS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAlveolar Bone Loss*-
dc.subject.MESHAlveolar Process / diagnostic imaging-
dc.subject.MESHAlveolar Process / surgery-
dc.subject.MESHAlveolar Ridge Augmentation*-
dc.subject.MESHAnimals-
dc.subject.MESHDogs-
dc.subject.MESHPeriodontal Ligament-
dc.subject.MESHTooth Extraction-
dc.subject.MESHTooth Socket / diagnostic imaging-
dc.subject.MESHTooth Socket / surgery-
dc.titleImmediate versus delayed application of bone morphogenetic protein-2 solution in damaged extraction sockets: a preclinical in vivo investigation-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Periodontics (치주과학교실)-
dc.contributor.googleauthorMyong Ji Kim-
dc.contributor.googleauthorJae-Kook Cha-
dc.contributor.googleauthorKyeong-Won Paeng-
dc.contributor.googleauthorYoung Woo Song-
dc.contributor.googleauthorDaniel S Thoma-
dc.contributor.googleauthorRonald E Jung-
dc.contributor.googleauthorUi-Won Jung-
dc.identifier.doi10.1007/s00784-020-03362-w-
dc.contributor.localIdA05142-
dc.contributor.localIdA03692-
dc.contributor.localIdA04004-
dc.relation.journalcodeJ00601-
dc.identifier.eissn1436-3771-
dc.identifier.pmid32451759-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs00784-020-03362-w-
dc.subject.keywordAlveolar ridge augmentation-
dc.subject.keywordAnimal experimentation-
dc.subject.keywordBone morphogenetic protein 2-
dc.subject.keywordBone substitutes-
dc.subject.keywordDamaged extraction socket-
dc.subject.keywordExtraction socket regeneration-
dc.subject.keywordTooth extraction-
dc.contributor.alternativeNameSong, Young Woo-
dc.contributor.affiliatedAuthor송영우-
dc.contributor.affiliatedAuthor정의원-
dc.contributor.affiliatedAuthor차재국-
dc.citation.volume25-
dc.citation.number1-
dc.citation.startPage275-
dc.citation.endPage282-
dc.identifier.bibliographicCitationCLINICAL ORAL INVESTIGATIONS, Vol.25(1) : 275-282, 2021-01-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Periodontics (치주과학교실) > 1. Journal Papers

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