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Risk of Cancer Following the Use of N-Nitrosodimethylamine (NDMA) Contaminated Ranitidine Products: A Nationwide Cohort Study in South Korea

Authors
 Hong Jin Yoon  ;  Jie-Hyun Kim  ;  Gi Hyeon Seo  ;  Hyojin Park 
Citation
 JOURNAL OF CLINICAL MEDICINE, Vol.10(1) : 153, 2021-01 
Journal Title
JOURNAL OF CLINICAL MEDICINE
Issue Date
2021-01
Keywords
NDMA ; cancer risk ; claims data ; famotidine ; ranitidine
Abstract
N-nitrosodimethylamine (NDMA), a known carcinogenic agent, was recently detected in some products of ranitidine. Several studies have investigated the detectability of NDMA, in drugs and their risks. However, only a few epidemiological studies have evaluated cancer risk from the use of such individual drugs. This study investigates the risk of cancer in ranitidine users. We conducted an observational population-based cohort study using the Health Insurance Review and Assessment databases, which contain information about the use of medicines in South Korea. The primary study cohort consisted of ranitidine users (n = 88,416). For controls, we enrolled users of famotidine, another H2-receptor antagonist in which no NDMA has been detected. A 4:1 matched cohort was constructed to compare cancer outcomes of the two groups. Our matched cohort comprised of 40,488 ranitidine users and 10,122 famotidine users. There was no statistical difference in the overall cancer risk between the ranitidine and famotidine groups (7.45% vs. 7.56%, HR 0.99, 95% CI 0.91-1.07, p = 0.716). Additionally, no significant differences were observed in the analysis of 11 single cancer outcomes. We found no evidence that exposure to NDMA through ranitidine increases the risk of cancer.
Files in This Item:
T202100155.pdf Download
DOI
10.3390/jcm10010153
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jie-Hyun(김지현) ORCID logo https://orcid.org/0000-0002-9198-3326
Park, Hyo Jin(박효진) ORCID logo https://orcid.org/0000-0003-4814-8330
Yoon, Hong Jin(윤홍진) ORCID logo https://orcid.org/0000-0002-4880-3262
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/181990
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